Journal ArticleDOI
Simultaneous determination of eight alkaloids and oleandrin in herbal cosmetics by dispersive solid-phase extraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry.
TLDR
In this article, the authors used ultra-high performance liquid chromatography with tandem mass spectrometry and dispersive solid-phase extraction to detect nine analytes (scopolamine, cephaeline, strychnine, hyoscyamine, brucine, hydrastine, ajmalicine, colchicine and oleandrin) in herbal cosmetics.Abstract:
We utilized ultra-high performance liquid chromatography with tandem mass spectrometry and dispersive solid-phase extraction to develop a new method for the detection of nine analytes (scopolamine, cephaeline, strychnine, hyoscyamine, brucine, hydrastine, ajmalicine, colchicine, and oleandrin) in herbal cosmetics. Acetonitrile/water and 2-propylaminoethylamine were used to disperse and purify during the dispersive solid-phase extraction step. The analytes were separated by a Waters UPLC HSS T3 column and detected through electrospray ionization source in the positive mode with multi-reaction monitoring conditions. Under the optimal conditions, the calibration curves were linear in the range of 0.2-100.0 μg/L with the correlation coefficients higher than 0.995. The method limit of quantitation (S/N = 10) were 5.0 μg/kg for oleandrin and 1.0 μg/kg for the other eight alkaloids. The mean recoveries at three spiked concentration levels of 1.0-10.0 μg/kg were in the range of 86.9-116.5% with the intra-day relative standard deviations (n = 6) ranging from 2.4 to 8.8%, and inter-day relative standard deviations ranging from 2.7 to 5.7%. This method is accurate, simple and rapid, and has been applied to the quality supervision of herbal cosmetics in Guangzhou.read more
Citations
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Interpol review of controlled substances 2016–2019
TL;DR: This review paper covers the forensic-relevant literature in controlled substances from 2016 to 2019 as a part of the 19th Interpol International Forensic Science Managers Symposium.
Journal Article
Ultra-performance liquid chromatography–tandem mass spectrometric method for the determination of strychnine and brucine in mice plasma
TL;DR: In this article, a method-ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for determination of two toxic alkaloids, namely strychnine and brucine in mice plasma.
Journal ArticleDOI
Enhanced cleanup efficiency hydroxy functionalized-magnetic graphene oxide and its comparison with magnetic carboxyl-graphene for PRiME pass-through cleanup of strychnine and brucine in human plasma samples.
Jian-Bo Ma,Hai-Wen Qiu,Qiu-Hong Rui,Yu-Feng Liao,Yan-Min Chen,Jin Xu,Yun Zhang,Yan Zhu,Yong-Gang Zhao,Yong-Gang Zhao +9 more
TL;DR: Validation results on linearity, specificity, accuracy and precision, as well as on the application to analysis ofStrychnine and brucine in six cases of suspected semen strychni poisoning demonstrate the applicability to clinical studies.
Journal ArticleDOI
Development of a UHPLC-MS/MS method for the quantitation of bioactive compounds in Phyllanthus species and its herbal formulations.
Sunil Kumar,Awantika Singh,Awantika Singh,Vikas Bajpai,Vikas Bajpai,Bikarma Singh,Brijesh Kumar,Brijesh Kumar +7 more
TL;DR: The results indicated that the present method could be used for quality control of Phyllanthus species and its herbal formulations.
Journal ArticleDOI
Scopolamine analysis in beverages: bicolorimetric device vs portable nano liquid chromatography
TL;DR: A sensor for SCP is described based on the entrapment of KMnO4 into polydimethylsiloxane (PDMS), which reacts rapidly with SCP under basic conditions causing a change of the color of the solution that can be related to the concentration of drug using both, absorbances and color coordinates.
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