Journal ArticleDOI
Sleep timing and the circadian clock in mammals: Past, present and the road ahead.
TLDR
A review of the current understanding of the circadian regulation of sleep can be found in this paper, where the authors discuss the neural circuitry and molecular mechanisms underlying daily sleep timing, and the trajectory of circadian regulation across development.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2021-06-03. It has received 15 citations till now. The article focuses on the topics: Circadian rhythm & Biology.read more
Citations
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Journal ArticleDOI
Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands
TL;DR: These results highlight comprehensive characterization of insufficient sleep–affected ELG circadian transcriptome that may provide a new therapeutic approach to counteract the effects of SD on ELG function.
Journal ArticleDOI
Chronic corticosterone disrupts the circadian rhythm of CRH expression and m6A RNA methylation in the chicken hypothalamus
TL;DR: In this paper , the effects of chronic exposure to corticosterone (CORT) eliminated the diurnal patterns of plasma CORT and melatonin levels in the chicken, leading to dysfunction of the HPA axis.
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Top-down and bottom-up alterations of connectivity patterns of the suprachiasmatic nucleus in chronic insomnia disorder.
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Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions
Cunsi Ye,Yajing Zhang,Shao-Yu Lin,Yi Chen,Zimiao Wang,Haoyinghua Feng,Guangqing Fang,Shi-jian Quan +7 more
TL;DR: In this article , the protein levels of Clock and Bmal1 were decreased in metabolic-associated fatty liver disease (MAFLD) mice, which was negatively correlated with elevated reactive oxygen species (ROS) accumulation, the H2O2 level, liver inflammation, metabolic dysfunction, and insulin resistance.
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The stress of losing sleep: Sex-specific neurobiological outcomes
TL;DR: In this paper , a review discusses sex differences in response to sleep deprivation, with a focus on the sympathetic nervous system stress response and activation of the hypothalamic-pituitary-adrenal (HPA) axis.
References
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Journal ArticleDOI
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
Christelle Peyron,Devin K. Tighe,Anthony N. van den Pol,Anthony N. van den Pol,Luis de Lecea,H. Craig Heller,J. Gregor Sutcliffe,Thomas S. Kilduff +7 more
TL;DR: The results of this immunohistochemical study suggest that hypocretins are likely to have a role in physiological functions in addition to food intake such as regulation of blood pressure, the neuroendocrine system, body temperature, and the sleep–waking cycle.
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Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
TL;DR: It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other non–image-forming visual functions.
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Hypothalamic regulation of sleep and circadian rhythms
TL;DR: These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake–sleep cycles into the optimal pattern for survival.
Journal ArticleDOI
Life between clocks: daily temporal patterns of human chronotypes.
TL;DR: It is predicted that the timing of sleep has changed during industrialization and that a majority of humans are sleep deprived during the workweek, and the implications are far ranging concerning learning, memory, vigilance, performance, and quality of life.
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.