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Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Michelle R. Arkin,James A. Wells +1 more
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Here, illustrative examples are used to discuss general strategies for addressing the challenges inherent in the discovery and characterization of small-molecule inhibitors of protein–protein interactions.Abstract:
Protein–protein interactions have a key role in most biological processes, and offer attractive opportunities for therapeutic intervention. Developing small molecules that modulate protein–protein interactions is difficult, owing to issues such as the lack of well-defined binding pockets. Nevertheless, there has been important progress in this endeavour in recent years. Here, we use illustrative examples to discuss general strategies for addressing the challenges inherent in the discovery and characterization of small-molecule inhibitors of protein–protein interactions.read more
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Cancer Genome Landscapes
Bert Vogelstein,Nickolas Papadopoulos,Victor E. Velculescu,Shibin Zhou,Luis A. Diaz,Kenneth W. Kinzler +5 more
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The re-emergence of natural products for drug discovery in the genomics era
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Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
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Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
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Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept
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References
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The structure and function
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