Journal ArticleDOI
Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies
TLDR
This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.About:
This article is published in Materials Science and Engineering: C.The article was published on 2016-11-01. It has received 250 citations till now. The article focuses on the topics: Drug delivery & Eye disorder.read more
Citations
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Journal ArticleDOI
Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
Vijay Mishra,Kuldeep K. Bansal,Asit Verma,Nishika Yadav,Sourav Thakur,Kalvatala Sudhakar,Jessica M. Rosenholm +6 more
TL;DR: Light is shed on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.
Journal ArticleDOI
Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release
TL;DR: The importance of obtaining a detailed knowledge of the structure of the lipid nanoparticles is highlighted, which is useful for the rational design of this type of nanocarriers and propose solutions to the challenges involved in their formulation.
Journal ArticleDOI
Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review
TL;DR: Despite the cutaneous use of SLN and NLC has been proposed for both local and transdermal delivery, the reported studies show promising results only for local application, so more research is required to better understanding the interaction mechanisms of lipid nanoparticles with skin lipids.
Journal ArticleDOI
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
TL;DR: The currently active clinical trials on lipid nanoparticles were reviewed, with a brief discussion on what achievements or milestones are still to be reached, as a way of understanding the reasons for the scarce number of solid lipid nanoparticle undergoing clinical trials.
References
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Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Toxicity of cationic lipids and cationic polymers in gene delivery.
TL;DR: The structural features of cationic compounds are evaluated and the relationship of toxicity and structure is summarized and available suggestions are provided to provide available suggestions on the development of these cATIONic compounds.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
Journal ArticleDOI
Solid lipid nanoparticles for parenteral drug delivery.
TL;DR: The biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed.
Journal ArticleDOI
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
TL;DR: An overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown and the lipid nanoparticles are a "nanosafe" carrier.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more