Somatostatin inhibits VIP‐ and isoproterenol‐stimulated cyclic AMP accumulation in rat prostatic epithelial cells
TLDR
In addition to the multifactorial regulation of the cyclic AMP system in rat prostatic epithelium, these results suggest that somatostatin may play a physiological role at this level.About:
This article is published in FEBS Letters.The article was published on 1987-06-22 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Delta cell & Somatostatin.read more
Citations
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Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications.
TL;DR: Endocrine-paracrine cells of the prostate constitute, in addition to the basal and exocrine secretory cells, a third population of highly specialized epithelial cells in the prostate gland, which probably play a significant role during prostatic growth and differentiation as well as regulating the secretory process of the mature gland.
Journal ArticleDOI
Neuroendocrine differentiation in human prostatic carcinoma
TL;DR: The more basic implications of endocrine- paracrine cells and neuroendocrine differentiation are speculated on in reference to prostatic carcinogenesis and autocrine/paracrine tumor growth factor activity.
Journal ArticleDOI
Differential effects of peptide hormones bombesin, vasoactive intestinal polypeptide and somatostatin analog RC-160 on the invasive capacity of human prostatic carcinoma cells.
TL;DR: The results suggest that certain neuroendocrine peptides can increase the invasive potential of prostatic carcinoma cells and may thereby contribute to the rapid progression and aggressive clinical course of prostate tumors containing neuro endocrine elements.
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Involvement of corticotropin-releasing factor in restraint stress-induced anorexia and reversion of the anorexia by somatostatin in the rat.
Tamotsu Shibasaki,Naoko Yamauchi,Yumiko Kato,Akitsugu Masuda,Toshihiro Imaki,Mari Hotta,Hiroshi Demura,Hideto Oono,Nicholas Ling,Kazuo Shizume +9 more
TL;DR: The mechanism by which restraint stress induces suppression of food intake and the influence of intracerebroventricular (icv) administration of somatostatin on the anorexia induced by restraint stress were examined in the rat, providing further evidence in support of the theory that CRF is involved in the inhibitory mechanism ofFood intake in restraint stress.
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Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells
TL;DR: Two endocrinologically active octapeptide analogues of SRIF function as SCLC SRIF receptor agonists.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate
TL;DR: A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase.
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The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes.
Bruce D. Koch,Agnes Schonbrunn +1 more
TL;DR: As with receptors known to regulate adenylate cyclase by interaction with a guanine nucleotide regulatory subunit, SRIF receptor binding was decreased in the presence of guanines nucleotides, and SRIF inhibition of adenYLate Cyclase appears to be receptor mediated.
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Somatostatin inhibits basal and vasoactive intestinal peptide-stimulated hormone release by different mechanisms in GH pituitary cells.
TL;DR: Results support the conclusion that both compounds stimulate PRL secretion by a cAMP-mediated mechanism which can be fully activated by either one alone and indicate that changes in cAMP levels mediate inhibition of VIP-stimulated hormone secretion by SRIF.