Journal ArticleDOI
Speed cells in the medial entorhinal cortex
TLDR
It is shown that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells.Abstract:
Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment For this translation to occur, grid cells must have continuous access to information about instantaneous running speed However, a powerful entorhinal speed signal has not been identified Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50-80 ms Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortexread more
Citations
More filters
Journal ArticleDOI
Perineuronal nets stabilize the grid cell network
Ane Charlotte Christensen,Kristian Kinden Lensjø,Mikkel Elle Lepperød,Svenn-Arne Dragly,Hallvard Sutterud,Jan Sigurd Blackstad,Marianne Fyhn,Torkel Hafting +7 more
TL;DR: It is shown that removal of perineuronal nets leads to lower inhibitory spiking activity, and reduces grid cells’ ability to create stable representations of a novel environment, and that PNN removal in entorhinal cortex distorted spatial representations in downstream hippocampal neurons.
Journal ArticleDOI
Differential influences of environment and self-motion on place and grid cell firing.
TL;DR: Virtual reality is used to dissociate visual environmental from physical motion inputs, while recording place and grid cells in mice navigating virtual open arenas to show that place cells predominantly encode environmental sensory input, while grid cell activity reflects a greater influence of physical motion.
Journal ArticleDOI
Vector-based navigation using grid-like representations in artificial agents
Andrea Banino,Caswell Barry,Benigno Uria,Charles Blundell,Timothy P. Lillicrap,Piotr Mirowski,Alexander Pritzel,Martin J. Chadwick,Thomas Degris,Joseph Modayil,Greg Wayne,Hubert Soyer,Fabio Viola,Brian Hu Zhang,Ross Goroshin,Neil C. Rabinowitz,Razvan Pascanu,Charles Beattie,Stig Petersen,Amir Sadik,Stephen Gaffney,Helen King,Koray Kavukcuoglu,Demis Hassabis,Raia Hadsell,Dharshan Kumaran +25 more
TL;DR: These findings show that emergent grid-like representations furnish agents with a Euclidean spatial metric and associated vector operations, providing a foundation for proficient navigation, and support neuroscientific theories that see grid cells as critical for vector-based navigation.
Journal ArticleDOI
Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit
TL;DR: Neurons involved in this representation overlapped with the known spatial cell types in the circuit, such as place cells and grid cells, suggesting that common circuit mechanisms in the hippocampal–entorhinal system are used to represent diverse behavioural tasks, possibly supporting cognitive processes beyond spatial navigation.
Journal ArticleDOI
Rhythms of the hippocampal network
TL;DR: The current understanding of the origins and the mnemonic functions of hippocampal theta, sharp wave–ripples and gamma rhythms is discussed on the basis of findings from rodent studies and an updated synthesis of their roles and interactions within the hippocampal network is presented.
References
More filters
Journal ArticleDOI
Microstructure of a spatial map in the entorhinal cortex
TL;DR: The dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial environment, whose key unit is the ‘grid cell’, which is activated whenever the animal's position coincides with any vertex of a regular grid of equilateral triangles spanning the surface of the environment.
Journal ArticleDOI
Phase relationship between hippocampal place units and the EEG theta rhythm
John O'Keefe,Michael Recce +1 more
TL;DR: The phase was highly correlated with spatial location and less well correlated with temporal aspects of behavior, such as the time after place field entry, and the characteristics of the phase shift constrain the models that define the construction of place fields.
Journal ArticleDOI
Path integration and the neural basis of the 'cognitive map'
Bruce L. McNaughton,Bruce L. McNaughton,Francesco P. Battaglia,Ole Jensen,Edvard I. Moser,May-Britt Moser +5 more
TL;DR: Theoretical studies suggest that the medial entorhinal cortex might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation.
Journal ArticleDOI
Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences.
TL;DR: Large‐scale parallel recordings are made use of to clarify and extend the finding that a cell's spike activity advances to earlier phases of the theta cycle as the rat passes through the cell's place field, and to show Granule cells of the fascia dentata are also modulated by theta.
Journal ArticleDOI
Instant neural control of a movement signal.
Mijail D. Serruya,Nicholas G. Hatsopoulos,Nicholas G. Hatsopoulos,Liam Paninski,Liam Paninski,Matthew R. Fellows,John P. Donoghue +6 more
TL;DR: In this paper, the activity from a few motor cortex neurons can be decoded into a signal that a monkey is able to use immediately to move a computer cursor to any new position in its workspace.