Spirulina maxima Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical Trial
Jesús Martínez-Sámano,Adriana Torres-Montes de Oca,Oscar Ivan Luqueño-Bocardo,Patricia V. Torres-Durán,Marco Antonio Juárez-Oropeza +4 more
TLDR
The effects found in the present study agree with antihypertensive and antioxidant effects previously reported for Spirulina maxima, however, this is the first report about the effects on indicators of endothelial damage and oxidative stress indicators.Abstract:
(1) Background: Spirulina (Arthrospira) maxima has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension (SAH) undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators. The blood levels of sICAM-1, sVCAM-1, endothelin-1, and sE-selectin were quantified; the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and concentrations of reduced glutathione, oxidized glutathione, and thiobarbituric acid reactive substances, were also quantified before and after the treatment period. (3) Results: There were statistically significant (p < 0.05) decreases in systolic blood pressure, sVCAM-1, sE-selectin and endothelin-1 levels, and increases in glutathione peroxidase activity and oxidized glutathione levels. (4) Conclusion: The effects found in the present study agree with antihypertensive and antioxidant effects previously reported for Spirulina maxima. However, this is the first report about the effects on indicators of endothelial damage. More research in this field is necessary to gain an insight into the effects of Spirulina on these indicators.read more
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Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
Adam S. Cifu,Andrew M. Davis +1 more
TL;DR: This guideline was developed by the ACC and the AHA in partnership with other professional societies with a writing committee notable for its inclusion of people with a breadth of backgrounds, wide scope of practice, and freedom from conflicts of interest.
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The effect of diet on oxidative stress and metabolic diseases-Clinically controlled trials.
María Luisa Ávila-Escalante,Fibi Yenisie Coop-Gamas,Margarita Cervantes-Rodríguez,Daniel Méndez-Iturbide,Irma Aranda-González +4 more
TL;DR: An update of clinical controlled trials, to assess changes in diet and markers of oxidative stress in subjects with metabolic diseases, and food antioxidants, hypocaloric diets with loss of adipose tissue, substitution of animal protein by vegetable, and changes in the microbiota improve antioxidant status in people with chronic disease.
Journal ArticleDOI
Protective Effect of Spirulina platensis Extract against Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Rats.
Mohamed A. Morsy,Sumeet Gupta,Anroop B. Nair,Katharigatta N. Venugopala,Katharigatta N. Venugopala,Khaled Greish,Mahmoud El-Daly +6 more
TL;DR: The hydroalcoholic extract of Spirulina platensis dose-dependently modulated all DSS-induced inflammatory changes and significantly lowered only IL-6 and ESR, but not TNF-α or MPO levels.
Journal ArticleDOI
A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases.
Albino Carrizzo,Carmine Izzo,Maurizio Forte,Eduardo Sommella,Paola Di Pietro,Eleonora Venturini,Michele Ciccarelli,Gennaro Galasso,Speranza Rubattu,Petro Campiglia,Sebastiano Sciarretta,Giacomo Frati,Carmine Vecchione +12 more
TL;DR: The role of the most studied nutraceuticals, such as resveratrol, cocoa, quercetin, curcumin, brassica, berberine and Spirulina platensis, on different CVDs is examined.
Journal ArticleDOI
Solid Matrix-Supported Supercritical CO₂ Enhances Extraction of γ-Linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation of the Molecule in Zebrafish.
TL;DR: A novel solid matrix-supported supercritical CO2 extraction method for scalable isolation of the PUFA γ-linolenic acid (GLA)-enriched glycolipids from the cyanobacterium Arthrospira (Spirulina) platensis, which has been the most widely used among microalgae in the nutraceutical and pharmaceutical industries.
References
More filters
Journal ArticleDOI
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2011 Update A Report From the American Heart Association
Véronique L. Roger,Alan S. Go,Donald M. Lloyd-Jones,Robert J. Adams,Jarett D. Berry,Todd M. Brown,Mercedes R. Carnethon,Shifan Dai,Giovanni de Simone,Earl S. Ford,Caroline S. Fox,Heather J. Fullerton,Cathleen Gillespie,Kurt J. Greenlund,Susan M. Hailpern,John A. Heit,P. Michael Ho,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Diane M. Makuc,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Wayne D. Rosamond,Paul D. Sorlie,Randall S. Stafford,Tanya N. Turan,Melanie B. Turner,Nathan D. Wong,Judith Wylie-Rosett +40 more
TL;DR: Dariush Mozaffarian, Michael E. Mussolino, Graham Nichol, Nina P. Paynter, Wayne D. Sorlie, Randall S. Stafford, Tanya N. Turan, Melanie B. Turner, Nathan D. Turner.
Journal ArticleDOI
Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States.
Katharina Wolf-Maier,Richard S. Cooper,José R. Banegas,Simona Giampaoli,Hans-Werner Hense,Michel Joffres,Mika Kastarinen,Neil R Poulter,Paola Primatesta,Fernando Rodríguez-Artalejo,Birgitta Stegmayr,Michael Thamm,Jaakko Tuomilehto,Diego Vanuzzo,Fenicia Vescio +14 more
TL;DR: The 60% higher prevalence of hypertension in Europe compared with the United States and Canada has not been generally appreciated and the implication for national prevention strategies should be vigorously explored.
Journal ArticleDOI
The sympathetic control of blood pressure
TL;DR: This review examines how the sympathetic tone to cardiovascular organs is generated, and discusses how elevated sympathetic tone can contribute to hypertension.