Stereotactic body radiotherapy for localized prostate cancer: Pooled analysis from a multi-institutional consortium of prospective phase II trials
Christopher R. King,Debra Freeman,Irving D. Kaplan,Donald B. Fuller,Giampaolo Bolzicco,Sean P. Collins,Robert J. Meier,Jason Wang,Patrick A. Kupelian,Michael L. Steinberg,Alan W. Katz +10 more
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TLDR
PSA relapse-free survival rates after SBRT compare favorably with other definitive treatments for low and intermediate risk patients, and the current evidence supports consideration of S BRT among the therapeutic options for these patients.About:
This article is published in Radiotherapy and Oncology.The article was published on 2013-11-01 and is currently open access. It has received 394 citations till now. The article focuses on the topics: PSA Failure & Androgen deprivation therapy.read more
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Radiothérapie stéréotaxique extracrânienne : quelle machine pour quelle indication ? Stéréotaxie prostatique
A. Lapierre,S. Horn,Gilles Créhange,C. Enachescu,I. Latorzeff,Stéphane Supiot,Paul Sargos,C. Hennequin,O. Chapet +8 more
TL;DR: An overview of the published trials of stereotactic body radiotherapy is given, and the major differences between the machines are pointed out, from a clinical, technical, technical and radiobiological point of view.
Journal ArticleDOI
Ultra-hypofractionated radiation therapy for unfavourable intermediate-risk and high-risk prostate cancer is safe and effective: 5-year outcomes of a phase II trial.
TL;DR: To report toxicity (primary endpoint) and biochemical disease‐free survival (BDFS) outcomes of a phase II trial evaluating ultra‐hypofractionated radiation therapy (UHRT), focusing on patients with unfavourable intermediate‐risk and high‐risk prostate cancer (PCa).
Journal ArticleDOI
Prostate SBRT: Comparison the Efficacy and Toxicity of Two Different Dose Fractionation Schedules.
TL;DR: A practical strategy could be to more strongly consider the high dose regimen in those with the greatest potential longevity, while for those with a more limited longevity, particularly if they have minimal negative prognostic factors, the moderate dose regimen could be more attractive.
Journal ArticleDOI
Stereotactic body radiation therapy: Let's not give up on progress.
James B. Yu,Howard M. Sandler +1 more
TL;DR: Stereotactic body radiation therapy (SBRT) is a promising radiation therapy technique that delivers larger fractions of radiation more precisely than standardly fractionated radiation, and is likely more convenient in treating cancers that have long treatment courses.
Journal ArticleDOI
Hypofractionated intensity-modulated radiation therapy for prostate cancer confined to the pelvis: analysis of efficacy and late toxicity
Yueping Liu,Phillip J. Gray,Jing Jin,Weihu Wang,Hui Fang,Shulian Wang,Yongwen Song,Hua Ren,Xin-Fan Liu,Zi-Hao Yu,Jian-Rong Dai,Yexiong Li +11 more
TL;DR: Moderately hypofractionated IMRT for prostate cancer is efficacious and well-tolerated in this predominantly high-risk, locally advanced, or N1 Chinese patients and is associated with low rates of severe late toxicity during early follow-up.
References
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Journal ArticleDOI
Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer.
TL;DR: Significant late bladder and rectal toxicities from SBRT for prostate cancer are infrequent and the current evidence supports consideration of stereotactic body radiotherapy among the therapeutic options for localized prostate cancer.
Journal ArticleDOI
Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience.
TL;DR: The outcomes after high-dose hypofractionation were acceptable in the entire cohort of patients treated with the schedule of 70 at 2.5 Gy/fraction and the 5-year nadir + 2 ng/mL rate was 83% (95% confidence interval, 79–86%).
Journal ArticleDOI
Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: First clinical trial results
TL;DR: In this paper, the feasibility and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer were evaluated in a Phase I/II trial with 40 patients.
Journal ArticleDOI
Randomized trial comparing two fractionation schedules for patients with localized prostate cancer.
Himu Lukka,Charles Hayter,Jim A. Julian,Padraig Warde,W. James Morris,Mary Gospodarowicz,Mark Levine,Jinka Sathya,Richard Choo,Hugh M. Prichard,Michael Brundage,Winkle Kwan +11 more
TL;DR: This study was designed as a noninferiority investigation with a predefined tolerance of −7.5%.
Journal ArticleDOI
Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial
David P. Dearnaley,Isabel Syndikus,Georges Sumo,M. Bidmead,D. Bloomfield,Catharine H. Clark,Annie Gao,Shama Hassan,Alan Horwich,Robert Huddart,Vincent Khoo,Peter Kirkbride,Helen Mayles,P. Mayles,O. Naismith,Chris Parker,Helen Patterson,Martin J. Russell,Christopher D Scrase,C. South,John Staffurth,Emma Hall +21 more
TL;DR: A pre-planned preliminary safety analysis of side-effects in stages 1 and 2 of a randomised trial comparing standard and hypofractionated radiotherapy seems equally well tolerated as conventionally fractionated treatment at 2 years.
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