Journal ArticleDOI
Steroid hormone receptors compete for factors that mediate their enhancer function
M. E. Meyer,Hinrich Gronemeyer,Hinrich Gronemeyer,Bernard Turcotte,Bernard Turcotte,M. T. Bocquel,M. T. Bocquel,Diane Tasset,Diane Tasset,Pierre Chambon,Pierre Chambon +10 more
TLDR
Stimulation of transcription of reporter genes by the progesterone receptor was inhibited in transfected HeLa cells by co-expressing the estrogen receptor (ER) in an ER-dose- and estrogen-dependent manner, and it is proposed that these observations reflect competition for a functionally limiting transcription factor(s).About:
This article is published in Cell.The article was published on 1989-05-05. It has received 551 citations till now. The article focuses on the topics: Estrogen receptor & Glucocorticoid receptor.read more
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A decade of molecular biology of retinoic acid receptors.
TL;DR: A review of recent developments in structure‐ function relationships of retinoic acid receptors focuses on recent developments, particularly in the area of structure‐function relationships.
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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
TL;DR: Results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily.
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Nuclear receptor coregulators: cellular and molecular biology.
TL;DR: This review will summarize selected aspects of the current knowledge of the cellular and molecular biology of nuclear receptor coregulators.
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Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
Carsten Jonat,Hans J. Rahmsdorf,Kun-Koo Park,Andrew C.B. Cato,Stephan Gebel,Helmut Ponta,Peter Herrlich +6 more
TL;DR: Coprecipitation experiments suggest direct AP-1-hormone receptor interaction, which also possibly explains the reverse experiment: overexpression of Fos or Jun inhibits the expression of hormone-dependent genes.
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Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
Hsin-Fang Yang-Yen,Jean-Claude Chambard,Yu-Lin Sun,Tod Smeal,Thomas J. Schmidt,Jacques Drouin,Michael Karin +6 more
TL;DR: Findings reveal a cross talk between two major signal transduction systems used to control gene transcription in response to extracellular stimuli, and a novel mechanism for transcriptional repression.
References
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
Stephen Green,P Walter,Vijay Kumar,Andrée Krust,Jean-Marc Bornert,Patrick Argos,Pierre Chambon +6 more
TL;DR: Cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7 and found extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
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Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks
TL;DR: Information is provided on how to identify the Steroid Receptors, Receptor Binding Sites, and other mechanisms that aid in the identification of the receptors and their locations in the genome.
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How eukaryotic transcriptional activators work
TL;DR: A specific protein, bound to DNA, can activate transcription of a wide array of genes in many eukaryotes and is controlled by the immune system.
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Functional domains of the human estrogen receptor.
TL;DR: Deletion of most or all of the hormone-binding domain leads to only about 5% constitutive transcriptional activity, yet these mutants appear to bind efficiently to an ERE in vivo.