Journal ArticleDOI
Structural and functional aspects of P-glycoprotein and its inhibitors.
Reads0
Chats0
TLDR
This review presents up‐to‐date information on the structural and functional aspects of P‐glycoprotein and its known inhibitors and provides some information on drug discovery approaches for candidate P‐gp inhibitors.About:
This article is published in Life Sciences.The article was published on 2018-12-01. It has received 102 citations till now. The article focuses on the topics: Drug discovery & ADME.read more
Citations
More filters
Journal ArticleDOI
Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update.
Jinyun Dong,Zuodong Qin,Weidong Zhang,Gang Cheng,Assaraf G. Yehuda,Charles R. Ashby,Zhe-Sheng Chen,Xiang-Dong Cheng,Jiang-Jiang Qin,Jiang-Jiang Qin +9 more
TL;DR: A comprehensive review of the synthetic and natural products that have specific inhibitory activity on P-gp drug efflux as well as promising chemosensitizing efficacy in MDR cancer cells is provided.
Journal ArticleDOI
WNT Signaling in Tumors: The Way to Evade Drugs and Immunity.
TL;DR: This pathway should be a main target in cancer therapy as WNT signaling activation is essential for tumor progression and survival, even in the presence of the anti-tumoral immune response and/or antineoplastic drugs.
Journal ArticleDOI
Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp).
TL;DR: Recent achievements in drug design, characterization, structure–activity relationship (SAR) studies, and mechanisms of action of the newly synthetic, potent small molecules P‐gp inhibitors in the past 5 years are highlighted.
Journal ArticleDOI
Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability
TL;DR: There are several hurdles that formulators must overcome when incorporating curcumin into commercial products, such as its low water solubility, chemical instability, rapid metabolism by enzymes in the human body, and limited bioavailability.
References
More filters
Book ChapterDOI
Mechanisms of multidrug resistance in cancer.
TL;DR: Identifying genes and mechanisms critical to the development of MDR in vivo and establishing a reliable method for analyzing clinical samples could help to predict theDevelopment of resistance and lead to treatments designed to circumvent it.
Journal ArticleDOI
Structure; activity relationships.
TL;DR: A full analysis of structure-activity relationships must therefore embrace the whole of classical biochemistry, to which must be added the growing mass of knowledge accumulating as the result of the development of chemotherapy, the fermentation industries, the plant protection industry and the control of organisms attacking manufactured goods.
Journal ArticleDOI
P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review.
TL;DR: In this paper, a review of P-glycoprotein (P-gp) inhibitors/blockers is presented, focusing only on major classes of naturally occurring inhibitors viz., flavonoids, coumarins, terpenoids, alkaloids and saponins.