Journal ArticleDOI
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
William I. Weis,Jerry H. Brown,Stephen Cusack,Stephen Cusack,James C. Paulson,John J. Skehel,Don C. Wiley +6 more
TLDR
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites, suggesting that antibodies neutralize virus infectivity by preventing virus-to-cell binding.Abstract:
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sialic acid fills the conserved pocket, demonstrating that it is the influenza virus receptor. The proximity of the antibody-binding sites suggests that antibodies neutralize virus infectivity by preventing virus-to-cell binding. The structures suggest approaches to the design of anti-viral drugs that could block attachment of viruses to cells.read more
Citations
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Journal ArticleDOI
Full-length genome sequences of the first H9N2 avian influenza viruses isolated in the Northeast of Algeria
Abdelheq Barberis,Amine Boudaoud,Angelina Gorrill,Josianne Loupias,Abdeljelil Ghram,Jihene Lachheb,N. Alloui,Mariette F. Ducatez +7 more
TL;DR: Characterized Algerian AIV isolates showed mutations that suggest increased zoonotic potential, and additional studies in animal models are required to investigate the pathogenicity of these H9N2 AIV strains.
Book ChapterDOI
Influenza Virus Antiviral Targets
TL;DR: The cyclopentane peramivir was developed by BioCryst, again based on the crystal structure of NA and its interactions with inhibitors, and the aim was to find an inhibitor that was readily synthesized and orally available and that did not induce resistance.
Journal ArticleDOI
Influenza haemagglutinin: illuminating fusion
TL;DR: The recently determined structure of influenza haemagglutinin at the pH of membrane fusion gives new insights into the mechanism of viral fusion, and is likely to stimulate further work on this best understood of all fusion proteins.
Patent
MOLECULAR CLONING OF GENOMIC AND cDNA SEQUENCES ENCODING CELLULAR RECEPTORS FOR POLIOVIRUS
TL;DR: In this paper, an isolated nucleic acid molecule was provided for the purpose of inducing the production of a polypeptide which has the biological activity of a receptor for the picornavirus.
Journal ArticleDOI
Phylogenetic, molecular and drug-sensitivity analysis of HA and NA genes of human H3N2 influenza A viruses in Guangdong, China, 2007-2011.
Ping Huang,L.-J. Liang,Nianmei Hou,Xin Zhang,W. Z. Su,Shouyi Yu,Yonghui Zhang,Jinju Wu,Wen Chen +8 more
TL;DR: Compared to the World Health Organization 2012 vaccine strains, Guangdong H3N2 strains varied genetically and antigenically to some degree.
References
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Journal ArticleDOI
The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
Journal ArticleDOI
Areas, volumes, packing and protein structure.
TL;DR: This review is concerned with the packing of groups of atoms in proteins and with the area of solvent-protein interfaces.
Journal ArticleDOI
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
Journal ArticleDOI
Aromatic-aromatic interaction: a mechanism of protein structure stabilization
TL;DR: Analysis of neighboring aromatic groups in four biphenyl peptides or peptide analogs and 34 proteins reveals a specific aromatic-aromatic interaction that helps stabilize tertiary structure, and 20 percent stabilize quaternary structure.
Journal ArticleDOI
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
TL;DR: Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified and at least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.
Related Papers (5)
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus
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