Journal ArticleDOI
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
William I. Weis,Jerry H. Brown,Stephen Cusack,Stephen Cusack,James C. Paulson,John J. Skehel,Don C. Wiley +6 more
TLDR
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites, suggesting that antibodies neutralize virus infectivity by preventing virus-to-cell binding.Abstract:
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sialic acid fills the conserved pocket, demonstrating that it is the influenza virus receptor. The proximity of the antibody-binding sites suggests that antibodies neutralize virus infectivity by preventing virus-to-cell binding. The structures suggest approaches to the design of anti-viral drugs that could block attachment of viruses to cells.read more
Citations
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Research Overview Development of Neuraminidase Inhibitors as Anti-Influenza Virus Drugs
TL;DR: Relenza as mentioned in this paper (Zanamivir/GG167) is an anti-influenza virus drug that targets the active site of neuraminidase, which has been totally conserved in both Type A and B influenza in all known subtypes of influenza.
Journal ArticleDOI
Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication.
Patrick Salmon,René Olivier,I Yves Riviere,I Edith Brisson,Jean Claude Gluckman,Marie-Paule Kieny,Luc Montagnier,David Klatzmann +7 more
TL;DR: The results suggest that the classical virus interference documented for other retroviruses might not only be due to receptor/envelope interaction, but might also depend on receptor gene expression.
Journal ArticleDOI
Fusomorphogenesis: cell fusion in organ formation.
Gidi Shemer,Benjamin Podbilewicz +1 more
TL;DR: In this article, a simple cellular mechanism to efficiently redistribute membranes using a combination of cell fusion and polarized membrane recycling during morphogenesis was proposed to explain how the intracellular machinery that drives fusomorphogenesis may have evolved.
Journal ArticleDOI
Sialylation of the Host Receptor May Modulate Entry of Demyelinating Persistent Theiler's Virus
TL;DR: The interaction of the receptor moiety with the persistent DA strain provides new understanding for the demyelinating persistent infection in the mouse CNS by TMEV.
Journal ArticleDOI
The human cytomegalovirus receptor on fibroblasts is a 30-kilodalton membrane protein.
H P Taylor,Neil R. Cooper +1 more
TL;DR: The present experiments suggest that a membrane protein with a molecular mass of approximately 30 kDa mediates HCMV binding to several cell types.
References
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Journal ArticleDOI
The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
Journal ArticleDOI
Areas, volumes, packing and protein structure.
TL;DR: This review is concerned with the packing of groups of atoms in proteins and with the area of solvent-protein interfaces.
Journal ArticleDOI
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
Journal ArticleDOI
Aromatic-aromatic interaction: a mechanism of protein structure stabilization
TL;DR: Analysis of neighboring aromatic groups in four biphenyl peptides or peptide analogs and 34 proteins reveals a specific aromatic-aromatic interaction that helps stabilize tertiary structure, and 20 percent stabilize quaternary structure.
Journal ArticleDOI
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
TL;DR: Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified and at least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.
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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
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