Journal ArticleDOI
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
William I. Weis,Jerry H. Brown,Stephen Cusack,Stephen Cusack,James C. Paulson,John J. Skehel,Don C. Wiley +6 more
TLDR
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites, suggesting that antibodies neutralize virus infectivity by preventing virus-to-cell binding.Abstract:
The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sialic acid fills the conserved pocket, demonstrating that it is the influenza virus receptor. The proximity of the antibody-binding sites suggests that antibodies neutralize virus infectivity by preventing virus-to-cell binding. The structures suggest approaches to the design of anti-viral drugs that could block attachment of viruses to cells.read more
Citations
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A High-Performance Plasmonic Nanosensor Based on an Elliptical Nanorod in an MIM Configuration
TL;DR: In this article, a surface plasmon resonance-based nanophotonic biosensor structure was proposed and numerically investigated, which provided an extremely high sensitivity and transmission efficiency with a high figure-of-merit (FOM).
Journal ArticleDOI
Rapid Diagnostic Assay for Intact Influenza Virus Using a High Affinity Hemagglutinin Binding Protein.
Caitlin E. Anderson,Carly A. Holstein,Eva-Maria Strauch,Steven Bennett,Aaron Chevalier,Jorgen Nelson,Elain Fu,David Baker,Paul Yager +8 more
TL;DR: This work describes the development of a novel influenza assay that targets the hemagglutinin protein and demonstrates the power of recombinant affinity proteins for use in rapid diagnostic assays.
Journal ArticleDOI
Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effect of Their Molecular Mobility on Interaction with the Influenza Virus.
TL;DR: Interestingly, glycopolymers with the medium length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.
Journal ArticleDOI
Synthesis of Methyl 6′-Deoxy- and 6′-Thiolactosaminides and Their Inhibitory Activity Toward CMP-NeuNAc:D-galactoside-(2→6)-α-D-sialyltransferase
TL;DR: Two kinds of substrate-analog inhibitors of glycosyltransferases are possible, and the donor analogs have been rather well studied, but are not specific.
Journal ArticleDOI
Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.
Avishekh Gautam,Byoung Kwon Park,Te Ha Kim,Madhav Akauliya,Dongbum Kim,Sony Maharjan,Joongwon Park,Jinsoo Kim,Hanseul Lee,Man Seong Park,Younghee Lee,Hyung-Joo Kwon +11 more
TL;DR: It is shown that intraperitoneal inoculation with A/WSN/1933 (H1N1) virus induced virus-reactive IgG production in the peritoneal cavity in mice, and comparative studies on various immune reactions after infection through different routes may contribute to better selection of vaccination routes in development of efficacious influenza vaccines.
References
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Journal ArticleDOI
The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
Journal ArticleDOI
Areas, volumes, packing and protein structure.
TL;DR: This review is concerned with the packing of groups of atoms in proteins and with the area of solvent-protein interfaces.
Journal ArticleDOI
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
Journal ArticleDOI
Aromatic-aromatic interaction: a mechanism of protein structure stabilization
TL;DR: Analysis of neighboring aromatic groups in four biphenyl peptides or peptide analogs and 34 proteins reveals a specific aromatic-aromatic interaction that helps stabilize tertiary structure, and 20 percent stabilize quaternary structure.
Journal ArticleDOI
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
TL;DR: Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified and at least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.
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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
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