Studies on polynucleotides. X. Enzymic degradation. Some properties and mode of action of spleen phosphodiesterase.
W.E. Razzell,H. G. Khorana +1 more
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This article is published in Journal of Biological Chemistry.The article was published on 1968-02-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Mode of action.read more
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Process for amplifying nucleic acid sequences
TL;DR: In this article, a process for amplifying any desired specific nucleic acid sequence contained in a mixture of nucleic acids or mixture thereof is described, which can be repeated as often as desired.
Journal ArticleDOI
A two-dimensional fractionation procedure for radioactive nucleotides
TL;DR: High-voltage ionophoresis is used in both dimensions for the two-dimensional fractionation of ribonuclease digests of 32P-labelled RNA and the determination of the sequence of a nucleotide by partial digestion with spleen phosphodiesterase.
Patent
Detection of specific sequences in nucleic acids
TL;DR: In this article, the authors proposed a method for diagnosis of genetic abnormalities or other genetic conditions which can be readily automated and is used to determine the presence or absence of a target sequence in a sample of denatured nucleic acid.
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A New Biology for a New Century
TL;DR: Biology today is at a crossroads, between the comfortable path of continuing to follow molecular biology's lead or the more invigorating one of seeking a new and inspiring vision of the living world, one that addresses the major problems in biology that 20th century biology could not handle and, so, avoided.
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Contributions of PCR-Based Methods to Plant Systematics and Evolutionary Biology
Andrea D. Wolfe,Aaron Liston +1 more
TL;DR: There are many other techniques aside from DNA sequencing in which PCR is appropriate and extremely useful, and these applications of PCR in plant systematics are reviewed.
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
TL;DR: A modification of the naphthalene-dioxane-PPO liquid scintillator has been described which will allow up to 3.0 ml of an aqueous solution to be counted as mentioned in this paper.
Journal ArticleDOI
The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.
Bruce N. Ames,Donald T. Dubin +1 more
TL;DR: The cations of T4 phage have been examined and a balance has been obtained between total cations and total DNA anions and the replacement of the normal polyamines suggested that the polyamines may be acting as nonspecific cations.