Journal ArticleDOI
Subclasses of vomeronasal receptor neurons : differential expression of G proteins (Giα2 and Goα) and segregated projections to the accessory olfactory bulb
Changping Jia,Mimi Halpern +1 more
TLDR
The results suggest that the existence of at least two subclasses of receptor neurons in the vomeronasal epithelium with differential projections to the AOB is a conserved feature among mammals.About:
This article is published in Brain Research.The article was published on 1996-05-06. It has received 257 citations till now. The article focuses on the topics: Vomeronasal receptor & Vomeronasal organ.read more
Citations
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Journal ArticleDOI
How the olfactory system makes sense of scents
TL;DR: Growing interest in the detection of diverse compounds at single-molecule levels has made the olfactory system an important system for biological modelling.
Journal ArticleDOI
A multigene family encoding a diverse array of putative pheromone receptors in mammals.
Hiroaki Matsunami,Linda B. Buck +1 more
TL;DR: A novel multigene family that codes for a diverse array of candidate pheromone receptors (VRs) expressed by the G alpha(o)+ subset is identified, suggesting a distributed mode of sensory coding.
Journal ArticleDOI
A New Multigene Family of Putative Pheromone Receptors
TL;DR: A new multigene family of G protein-linked receptors (V2Rs) that are specifically expressed in the VNO that are related to the Ca2+-sensing receptor and metabotropic glutamate receptors.
Journal ArticleDOI
Structure and function of the vomeronasal system: an update
TL;DR: New anatomical studies of the central pathways of the olfactory and vomeronasal systems indicated that these two systems converge on neurons in the telencephalon, providing an anatomical substrate for functional interactions.
Journal ArticleDOI
Ultrasensitive pheromone detection by mammalian vomeronasal neurons.
Trese Leinders-Zufall,Andrew P. Lane,Adam C. Puche,Weidong Ma,Milos V. Novotny,Michael T. Shipley,Frank Zufall +6 more
TL;DR: This work uses a mouse VNO slice preparation to show that six putative pheromones evoke excitatory responses in single vomeronasal neurons, leading to action potential generation and elevated calcium entry, providing a basis for understanding chemical signals that regulate mammalian communication and sexual behaviour.
References
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Journal ArticleDOI
G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
Journal ArticleDOI
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
Journal ArticleDOI
Diversity of G proteins in signal transduction.
TL;DR: The heterotrimeric guanine nucleotide-binding proteins acting as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors generate the pathways that modulate cellular responses to complex chemical signals.
Journal ArticleDOI
Heterotrimeric C proteins: Organizers of transmembrane signals
TL;DR: Some features of the structure and function of mammalian G protein subunits are summarized, then how the elements of the cellular language may be ordered and weighted to allow the cell to respond properly to the message is discussed.
Journal ArticleDOI
Topographic organization of sensory projections to the olfactory bulb
Robert Vassar,Steve K. Chao,Raquel Sitcheran,Jennifer M. Nuñez,Leslie B. Vosshall,Richard Axel +5 more
TL;DR: In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb, which supports a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set ofglomeruli.
Related Papers (5)
A novel family of genes encoding putative pheromone receptors in mammals
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A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution
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A multigene family encoding a diverse array of putative pheromone receptors in mammals.
Hiroaki Matsunami,Linda B. Buck +1 more