A novel family of genes encoding putative pheromone receptors in mammals
Catherine Dulac,Richard Axel +1 more
Reads0
Chats0
TLDR
Sequence analysis indicates that a family of about 30 putative receptor genes comprise a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE, likely to encode mammalian pheromone receptors.About:
This article is published in Cell.The article was published on 1995-10-20 and is currently open access. It has received 979 citations till now. The article focuses on the topics: Vomeronasal receptor & Vomeronasal organ.read more
Citations
More filters
Journal ArticleDOI
Molecular tinkering of G protein‐coupled receptors: an evolutionary success
Joël Bockaert,Jean-Philippe Pin +1 more
TL;DR: Indirect studies have led to a useful model of a common ‘central core’, composed of seven transmembrane helical domains, and its structural modifications during activation of G protein‐coupled receptors.
Journal ArticleDOI
A novel family of mammalian taste receptors.
Elliot Adler,Mark A. Hoon,Ken Mueller,Jayaram Chandrashekar,Nicholas J. P. Ryba,Charles S. Zuker +5 more
TL;DR: It is demonstrated that T2Rs couple to gustducin in vitro, and respond to bitter tastants in a functional expression assay, implying that they function as gust Ducin-linked receptors.
Journal ArticleDOI
Concerted and birth-and-death evolution of multigene families.
TL;DR: Until around 1990, most multigene families were thought to be subject to concerted evolution, in which all member genes of a family evolve as a unit in concert, but phylogenetic analysis of MHC and other immune system genes showed a quite different evolutionary pattern, and a new model called birth-and-death evolution was proposed.
Journal ArticleDOI
A spatial map of olfactory receptor expression in the Drosophila antenna.
TL;DR: A novel family of seven transmembrane domain proteins, encoded by 100 to 200 genes, that is likely to represent the family of Drosophila odorant receptors are identified and may ultimately afford a system to understand the mechanistic link between odor recognition and behavior.
Journal ArticleDOI
Mechanisms of olfactory discrimination : Converging evidence for common principles across phyla
TL;DR: The findings support the hypothesis that olfactory transduction and neural processing in the peripheral Olfactory pathway involve basic mechanisms that are universal across most species in most phyla.
References
More filters
Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
Journal ArticleDOI
Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
J. E. Krettek,Joseph L. Price +1 more
TL;DR: The efferent fiber connections of the nuclei of the amygdaloid complex with subcortical structures in the basal telencephalon, hypothalamus, midbrain, and pons have been studied in the rat and cat, using the autoradiographic method for tracing axonal connections.
Journal ArticleDOI
Topographic organization of sensory projections to the olfactory bulb
Robert Vassar,Steve K. Chao,Raquel Sitcheran,Jennifer M. Nuñez,Leslie B. Vosshall,Richard Axel +5 more
TL;DR: In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb, which supports a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set ofglomeruli.
Journal ArticleDOI
A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes.
TL;DR: A simple non-radioactive in situ hybridization procedure for tissue sections and cultured cells using digoxigenin-labelled cRNA probes for the detection of various transcripts present at a wide range of expression levels in the central nervous system is developed.
Related Papers (5)
A multigene family encoding a diverse array of putative pheromone receptors in mammals.
Hiroaki Matsunami,Linda B. Buck +1 more
A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution
Gilles Herrada,Catherine Dulac +1 more
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more