Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study.
Mika Kivimäki,Debbie A Lawlor,George Davey Smith,Marko Elovainio,Markus Jokela,Liisa Keltikangas-Järvinen,Jorma Viikari,Olli T. Raitakari +7 more
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TLDR
The findings were consistent with the fetal overnutrition hypothesis only in relation to birth weight, and the observed substantially higher adult BMI for offspring than for parents is likely explained by environmental influences.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2007-11-01 and is currently open access. It has received 105 citations till now. The article focuses on the topics: Offspring & Overnutrition.read more
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Animal models of obesity and diabetes mellitus
Maximilian Kleinert,Christoffer Clemmensen,Susanna M. Hofmann,Mary Courtney Moore,Simone Renner,Stephen C. Woods,Peter Huypens,Johannes Beckers,Martin Hrabé de Angelis,Annette Schürmann,Mostafa Bakhti,Martin Klingenspor,Mark L. Heiman,Alan D. Cherrington,Michael Ristow,Heiko Lickert,Eckhard Wolf,Peter J. Havel,Timo D. Müller,Matthias H. Tschöp +19 more
TL;DR: This Review consolidates the key information on the currently available animal models of obesity and diabetes and highlights the advantages, limitations and important caveats of each of these models.
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Comparing maternal and paternal intergenerational transmission of obesity risk in a large population-based sample
TL;DR: There is a strong and graded association between parental weight status and risk of childhood obesity, which is significantly stronger for maternal weight.
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Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Peter Huypens,Steffen Sass,Moya Wu,Daniela Dyckhoff,Matthias H. Tschöp,Fabian J. Theis,Susan Marschall,Martin Hrabě de Angelis,Johannes Beckers +8 more
TL;DR: Using in vitro fertilization to ensure exclusive inheritance via the gametes, it is shown that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin–specific mode.
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What is a cohort effect? Comparison of three statistical methods for modeling cohort effects in obesity prevalence in the United States, 1971-2006.
TL;DR: Age, period, and cohort (APC) effects on obesity prevalence in the U.S. from 1971 to 2006 are estimated using the classic constraint-based method, the Holford method, and median polish method to suggest that all methods report significant age and period effects.
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Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study
Romy Gaillard,Eric A.P. Steegers,Liesbeth Duijts,Janine F. Felix,Albert Hofman,Oscar H. Franco,Vincent W. V. Jaddoe +6 more
TL;DR: In this article, the associations of both maternal and paternal prepregnancy body mass index (BMI) with childhood body fat distribution and cardiometabolic outcomes and explored whether any association was explained by pregnancy, birth, and childhood factors.
References
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Establishing a standard definition for child overweight and obesity worldwide: international survey
TL;DR: The proposed cut off points, which are less arbitrary and more internationally based than current alternatives, should help to provide internationally comparable prevalence rates of overweight and obesity in children.
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Prevalence and Trends in Obesity Among US Adults, 1999-2000
TL;DR: The increases in the prevalences of obesity and overweight previously observed continued in 1999-2000, and increases occurred for both men and women in all age groups and for non-Hispanic whites, non- Hispanic blacks, and Mexican Americans.
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Obesity as a medical problem
TL;DR: The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society, and should be regarded as an epidemic that threatens global well being.
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Predicting Obesity in Young Adulthood from Childhood and Parental Obesity
TL;DR: Obese children under three years of age without obese parents are at low risk for obesity in adulthood, but among older children, obesity is an increasingly important predictor of adult obesity, regardless of whether the parents are obese.
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Childhood obesity: public-health crisis, common sense cure
TL;DR: In view of its rapid development in genetically stable populations, the childhood obesity epidemic can be primarily attributed to adverse environmental factors for which straightforward, if politically difficult, solutions exist.
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