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Journal ArticleDOI

Sudden death in psychiatric patients.

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TLDR
There is a need both for greater attention to suicide risk, most notably among young people with schizophrenia, to the early detection of cardiovascular disorders and to the vigorous management of comorbid substance misuse.
Abstract
BACKGROUND The present study investigated histories of prior psychiatric treatment in cases of sudden death reported to the coroner. METHODS A matching survey linked the register of deaths reported to the coroner with a comprehensive statewide psychiatric case register covering both in-patient and community-based services. RESULTS Sudden death was five times higher in people with histories of psychiatric contact. Suicide accounted for part of this excess mortality but deaths from natural causes and accidents were also elevated. Schizophrenic and affective disorders had similar suicide rates. Comorbid substance misuse doubled the risk of sudden death in affective and schizophrenic disorders. CONCLUSIONS The rates of sudden death are sufficiently elevated to raise questions about current priorities in mental health care. There is a need both for greater attention to suicide risk, most notably among young people with schizophrenia, to the early detection of cardiovascular disorders and to the vigorous management of comorbid substance misuse.

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Citations
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Journal ArticleDOI

A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?

TL;DR: In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention.
Journal ArticleDOI

Premature Mortality Among Adults With Schizophrenia in the United States

TL;DR: In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use, which highlight threats posed by substance abuse.
Journal ArticleDOI

Medical comorbidity in schizophrenia

TL;DR: Improved detection and treatment of medical illness in people with schizophrenia will have significant benefits for their psychosocial functioning and overall quality of life.
References
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Journal ArticleDOI

Suicide as an outcome for mental disorders. A meta-analysis.

TL;DR: Almost all mental disorders have an increased risk of suicide excepting mental retardation and dementia, which is highest for functional and lowest for organic disorders with substance misuse disorders lying between.
Journal ArticleDOI

Schizophrenia: A Life-shortening Disease

TL;DR: A 10-year followup of 1,190 patients with schizophrenia, selected from the Stockholm County inpatient register, showed that the overall mortality was about twice that in the general population, and the mortality in suicide was more than 10 times higher.
Journal ArticleDOI

A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland

TL;DR: Although there are several uncontrolled confounding factors, the overrepresentation of phenothiazines, especially thioridazine, among psychiatric patients who died suddenly is striking and, taken together with their well‐established arrhythmogenic effects, warrants further attention.
Journal ArticleDOI

Long-term course of hospitalization for schizophrenia: Part I. Risk for rehospitalization.

TL;DR: The probability of rehospitalization following the initial discharge on which a diagnosis of schizophrenia was made is described using data from psychiatric case registers in Victoria, Australia; Maryland, U.S.A.; Denmark; and Salford, England.
Journal ArticleDOI

Sudden death during treatment with phenothiazine derivatives.

Leo E. Hollister, +1 more
- 21 Jun 1965 - 
TL;DR: Six cases of sudden death occurred in otherwise healthy patients following treatment with phenothiazine derivatives in the fairly large doses customarily given to psychiatric patients, and this mode of death appears to be definitely associated with drug therapy.
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