Journal ArticleDOI
Sudden death in psychiatric patients.
David Ruschena,Paul E. Mullen,Philip Burgess,Stephen Cordner,Justin Barry-Walsh,Olaf H. Drummer,Simon Palmer,Chris Browne,Cameron Wallace +8 more
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TLDR
There is a need both for greater attention to suicide risk, most notably among young people with schizophrenia, to the early detection of cardiovascular disorders and to the vigorous management of comorbid substance misuse.Abstract:
BACKGROUND The present study investigated histories of prior psychiatric treatment in cases of sudden death reported to the coroner.
METHODS A matching survey linked the register of deaths reported to the coroner with a comprehensive statewide psychiatric case register covering both in-patient and community-based services.
RESULTS Sudden death was five times higher in people with histories of psychiatric contact. Suicide accounted for part of this excess mortality but deaths from natural causes and accidents were also elevated. Schizophrenic and affective disorders had similar suicide rates. Comorbid substance misuse doubled the risk of sudden death in affective and schizophrenic disorders.
CONCLUSIONS The rates of sudden death are sufficiently elevated to raise questions about current priorities in mental health care. There is a need both for greater attention to suicide risk, most notably among young people with schizophrenia, to the early detection of cardiovascular disorders and to the vigorous management of comorbid substance misuse.read more
Citations
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Journal ArticleDOI
A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
TL;DR: In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention.
Journal ArticleDOI
Physical illness in patients with severe mental disorders.I. Prevalence, impact of medications and disparities in health care
Marc De Hert,Christoph U. Correll,Julio Bobes,Marcelo Cetkovich-Bakmas,Dan Cohen,Itsuo Asai,Johan Detraux,S. Gautam,Hans-Jurgen Möller,David M. Ndetei,John W. Newcomer,Richard Uwakwe,Stefan Leucht +12 more
TL;DR: Prevalence rates of different physical illnesses as well as important individual lifestyle choices, side effects of psychotropic treatment and disparities in health care access, utilization and provision that contribute to these poor physical health outcomes are reported.
Journal ArticleDOI
Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III.
Joseph P. McEvoy,Jonathan M. Meyer,Donald C. Goff,Henry A. Nasrallah,Sonia M. Davis,Lisa M. Sullivan,Herbert Y. Meltzer,John K. Hsiao,T. Scott Stroup,Jeffrey A. Lieberman +9 more
TL;DR: The metabolic syndrome is highly prevalent in US schizophrenia patients and represents an enormous source of cardiovascular risk, especially for women, so clinical attention must be given to monitoring for this syndrome, and minimizing metabolic risks associated with antipsychotic treatment.
Journal ArticleDOI
Premature Mortality Among Adults With Schizophrenia in the United States
TL;DR: In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use, which highlight threats posed by substance abuse.
Journal ArticleDOI
Medical comorbidity in schizophrenia
TL;DR: Improved detection and treatment of medical illness in people with schizophrenia will have significant benefits for their psychosocial functioning and overall quality of life.
References
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Journal ArticleDOI
Suicide as an outcome for mental disorders. A meta-analysis.
E C Harris,B Barraclough +1 more
TL;DR: Almost all mental disorders have an increased risk of suicide excepting mental retardation and dementia, which is highest for functional and lowest for organic disorders with substance misuse disorders lying between.
Journal ArticleDOI
Schizophrenia: A Life-shortening Disease
TL;DR: A 10-year followup of 1,190 patients with schizophrenia, selected from the Stockholm County inpatient register, showed that the overall mortality was about twice that in the general population, and the mortality in suicide was more than 10 times higher.
Journal ArticleDOI
A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland
TL;DR: Although there are several uncontrolled confounding factors, the overrepresentation of phenothiazines, especially thioridazine, among psychiatric patients who died suddenly is striking and, taken together with their well‐established arrhythmogenic effects, warrants further attention.
Journal ArticleDOI
Long-term course of hospitalization for schizophrenia: Part I. Risk for rehospitalization.
William W. Eaton,Preben Bo Mortensen,Helen Herrman,Hugh Freeman,Warren Bilker,Philip Burgess,Kate Wooff +6 more
TL;DR: The probability of rehospitalization following the initial discharge on which a diagnosis of schizophrenia was made is described using data from psychiatric case registers in Victoria, Australia; Maryland, U.S.A.; Denmark; and Salford, England.
Journal ArticleDOI
Sudden death during treatment with phenothiazine derivatives.
Leo E. Hollister,Jon C. Kosek +1 more
TL;DR: Six cases of sudden death occurred in otherwise healthy patients following treatment with phenothiazine derivatives in the fairly large doses customarily given to psychiatric patients, and this mode of death appears to be definitely associated with drug therapy.