Supporting data for 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds
Daeha Joung,Vincent Truong,Colin C. Neitzke,Shuangzhuang Guo,Patrick J. Walsh,Joseph R. Monat,Fanben Meng,Sung Hyun Park,James R. Dutton,Ann M. Parr,Michael C. McAlpine +10 more
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TLDR
Successful bioprinting of OPCs in combination with sNPCs demonstrates a multicellular neural tissue engineering approach, where the ability to direct the patterning and combination of transplanted neuronal and glial cells can be beneficial in rebuilding functional axonal connections across areas of central nervous system tissue damage.Abstract:
The ability to model CNS tissues in vitro for in vivo transplantation has the potential to be of critical importance in a variety of medical conditions such as spinal cord injury, traumatic brain injury, stroke, and degenerative neurologic disease. Our approach to generating functional CNS tissue constructs relies on a “multiprong” combination of sophisticated 3D bioprinting and cell culture expertise. Here, as an example for utilizing novel 3D neurobioprinting, we have devised a method to model the cytoarchitecture of spinal cord tissue.read more
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3D printing of hydrogels: Rational design strategies and emerging biomedical applications
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
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A Review of 3D Printing Technologies for Soft Polymer Materials
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Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques
Mohsen Askari,Mohsen Askari,Moqaddaseh Afzali Naniz,Moqaddaseh Afzali Naniz,Monireh Kouhi,Azadeh Saberi,Ali Zolfagharian,Mahdi Bodaghi +7 more
TL;DR: This is a unique study to figure out the opportunities of the novel techniques to fabricate complicated constructs with structural and functional heterogeneity in hydrogel-based bioprinted scaffolds.
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3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments.
Fanben Meng,Carolyn Meyer,Daeha Joung,Daniel A. Vallera,Michael C. McAlpine,Angela Panoskaltsis-Mortari +5 more
TL;DR: These 3D vascularized tumor tissues provide a proof‐of‐concept platform to fundamentally explore the molecular mechanisms of tumor progression and metastasis, and preclinically identify therapeutic agents and screen anticancer drugs.
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Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery
TL;DR: This work discusses recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, tissue-engineering, microfluidic organ-chips, and humanized animal systems to enable more realistic models of human tissue function.
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Journal ArticleDOI
3D bioprinting of tissues and organs
Sean V. Murphy,Anthony Atala +1 more
TL;DR: 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation and developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.
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A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
TL;DR: An integrated tissue–organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape is presented and the incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100–200 μm for cell survival in engineered tissues.
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Cell-laden microengineered gelatin methacrylate hydrogels.
Jason W. Nichol,Sandeep T. Koshy,Sandeep T. Koshy,Sandeep T. Koshy,Hojae Bae,Hojae Bae,Chang M. Hwang,Chang M. Hwang,Seda Yamanlar,Seda Yamanlar,Ali Khademhosseini,Ali Khademhosseini +11 more
TL;DR: GelMA hydrogels could be useful for creating complex, cell- responsive microtissues, such as endothelialized microvasculature, or for other applications that require cell-responsive microengineered hydrogELs.
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3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs
David B. Kolesky,Ryan L. Truby,A. Sydney Gladman,Travis Alexander Busbee,Kimberly A. Homan,Jennifer A. Lewis +5 more
TL;DR: A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix that open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.