Journal ArticleDOI
Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system.
TLDR
The formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ofloxacin, based on the concept of pH-triggered in situ gelation is described, which was therapeutically efficacious, stable, non-irritant and provided sustained release of the drug over an 8-h period.About:
This article is published in Journal of Controlled Release.The article was published on 2001-06-15. It has received 322 citations till now. The article focuses on the topics: Antibacterial agent & Drug carrier.read more
Citations
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Journal ArticleDOI
In situ-forming hydrogels--review of temperature-sensitive systems.
TL;DR: This manuscript focuses on aqueous polymeric solutions that form implants in situ in response to temperature change, generally from ambient to body temperature, and mainly reviews the characterization and use of polysaccharides, N-isopropylacrylamide copolymers, poly(ethylene oxide) (poloxamer) and itsCopolymers.
Journal ArticleDOI
The use of mucoadhesive polymers in ocular drug delivery.
TL;DR: In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed.
Journal ArticleDOI
Mucoadhesive polymeric platforms for controlled drug delivery
TL;DR: The success and degree of muco-adhesive bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings as mentioned in this paper.
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Recent Perspectives in Ocular Drug Delivery
TL;DR: Several ocular drug delivery systems such as microemulsions, nanosuspensions, nanoparticles, liposomes, niosomes, dendrimers, implants, and hydrogels are discussed.
Journal ArticleDOI
Ocular release of timolol from molecularly imprinted soft contact lenses
TL;DR: Results indicate that imprinted soft contact lenses are promising drug devices able to provide greater and more sustained drug concentrations in tear fluid with lower doses than conventional eyedrops.
References
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Bioadhesive drug delivery systems: I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate
TL;DR: A group of fatty acid esters capable of forming liquid crystals has been identified as a new class of potential bioadhesive substances and it has been shown that the cubic phase is mucoadhesive when formed on wet mucosa, such as rabbit jejunum.
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Thermodynamic studies on the gel-sol transition of some pluronic polyols
TL;DR: In this article, a linear relationship was found between the logarithm of the pluronic polyol concentration and the reciprocal of the gel-sol transition temperature for all polymers having the same ratio of poly(oxypropylene) to poly (oxyethylene) units per mole of polymer, (P/E ratio).
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Gelrite®: A novel, ion-activated, in-situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol
TL;DR: In vivo, the formation of the gel prolonged precorneal residence time and increased ocular bioavailability of timolol in the cornea, aqueous humor and iris + ciliary body of albino rabbits.
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A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye
TL;DR: The overall results of this study indicate that the in situ-gelling alginate system, based on polymers with high G contents, is an excellent drug carrier for the prolonged delivery of pilocarpine.
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Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits
TL;DR: The gel formulation appeared to enhance the activity of pilocarpine when compared to the aqueous solution, relative to its suitability for use as a vehicle for ophthalmic drug delivery.