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Journal ArticleDOI

Synapses, networks, brain development – funding basic neuroscience research in Germany by the Schram Foundation

TLDR
The reader is introduced to the individual scientists who were awarded grants by the Schram Foundation over the years,some of the many discoveries made in the course of their studies and some of the key publications that arose from this work.
Abstract
Abstract Research driven solely by curiosity and the desire to understand fundamental principles of brain function. The freedom to address important questions with bold, sometimes risky experiments. A platform for open scientific exchange and discussions at highest academic level to provide new impulses to the field. And a growing number of scientists who share the passion for neuroscience and who join forces to tackle some of the big mysteries that surround the brain. These visions together with the deep conviction that basic research is the fundament needed for any progress in applied science motivated Dr. Armin Schram to create the foundation that carries his name. They are also the ideals that the foundation still pursues, and to date, 26 research proposals designed by individual researchers or small teams have been, or are, supported in this spirit. Here, we introduce the reader to the individual scientists who were awarded grants by the Schram Foundation over the years, highlight some of the many discoveries made in the course of their studies and list some of the key publications that arose from this work.

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Citations
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Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system

TL;DR: Kulkarni et al. as discussed by the authors showed that the birthdate of neurons in the fruit fly visual system helps organize them into layers, and that this clock helps arrange the growing cells into layers.
References
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Journal ArticleDOI

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function

TL;DR: It is shown that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord.
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SoxD Proteins Influence Multiple Stages of Oligodendrocyte Development and Modulate SoxE Protein Function

TL;DR: The authors showed that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord.
Journal ArticleDOI

Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.

TL;DR: It is concluded that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration.
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