Journal ArticleDOI
Synapses, networks, brain development – funding basic neuroscience research in Germany by the Schram Foundation
TLDR
The reader is introduced to the individual scientists who were awarded grants by the Schram Foundation over the years,some of the many discoveries made in the course of their studies and some of the key publications that arose from this work.Abstract:
Abstract Research driven solely by curiosity and the desire to understand fundamental principles of brain function. The freedom to address important questions with bold, sometimes risky experiments. A platform for open scientific exchange and discussions at highest academic level to provide new impulses to the field. And a growing number of scientists who share the passion for neuroscience and who join forces to tackle some of the big mysteries that surround the brain. These visions together with the deep conviction that basic research is the fundament needed for any progress in applied science motivated Dr. Armin Schram to create the foundation that carries his name. They are also the ideals that the foundation still pursues, and to date, 26 research proposals designed by individual researchers or small teams have been, or are, supported in this spirit. Here, we introduce the reader to the individual scientists who were awarded grants by the Schram Foundation over the years, highlight some of the many discoveries made in the course of their studies and list some of the key publications that arose from this work.read more
Citations
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Birth order dependent growth cone segregation determines synaptic layer identity in the Drosophila visual system
TL;DR: Kulkarni et al. as discussed by the authors showed that the birthdate of neurons in the fruit fly visual system helps organize them into layers, and that this clock helps arrange the growing cells into layers.
References
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Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
C. Claus Stolt,A Schlierf,Petra Lommes,Torsten Werner,Thomas Kosian,Elisabeth Sock,Nicoletta Kessaris,William D. Richardson,Lefebvre,Michael Wegner +9 more
TL;DR: It is shown that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord.
Journal ArticleDOI
SoxD Proteins Influence Multiple Stages of Oligodendrocyte Development and Modulate SoxE Protein Function
C. Claus Stolt,Anita Schlierf,Petra Lommes,Simone Hillgärtner,Torsten Werner,Thomas Kosian,Elisabeth Sock,Nicoletta Kessaris,William D. Richardson,Véronique Lefebvre,Michael Wegner +10 more
TL;DR: The authors showed that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord.
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Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression.
TL;DR: It is concluded that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration.
Journal ArticleDOI
Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus.
Anna Karpova,Marina Mikhaylova,Marina Mikhaylova,Sujoy Bera,Julia Bär,Pasham Parameshwar Reddy,Thomas Behnisch,Vladan Rankovic,Christina Spilker,Philipp Bethge,Jale Sahin,Rahul Kaushik,Werner Zuschratter,Thilo Kähne,Michael Naumann,Eckart D. Gundelfinger,Michael R. Kreutz +16 more
TL;DR: It is demonstrated that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic NMDAR signals and delivers them to the nucleus.