Open Access
Syncope and Its Consequences in Patients With Dementia Receiving Cholinesterase Inhibitors
Sudeep S. Gill,Geoffrey M. Anderson,Hadas D. Fischer,Chaim M. Bell,Ping Li,Sharon-Lise T. Normand,Paula A. Rochon +6 more
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The article was published on 2017-01-01 and is currently open access. It has received 254 citations till now. The article focuses on the topics: Dementia & Syncope (genus).read more
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A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager,Krista L. Lanctôt,Krista L. Lanctôt,Lana S. Rothenburg,Amy P. Wong,Amy P. Wong,Jaclyn Cappell,Nathan Herrmann,Nathan Herrmann +8 more
TL;DR: The results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β,IL-12 and IL-18 and higher CSF concentrations of T GF-β.
Journal ArticleDOI
Donepezil and memantine for moderate-to-severe Alzheimer's disease.
Robert Howard,Rupert McShane,James Lindesay,Craig W. Ritchie,Ashley Baldwin,Robert Barber,Alistair Burns,Tom Dening,David Findlay,Clive Holmes,Alan Hughes,Robin Jacoby,Robert G. Jones,Roy W. Jones,Ian G. McKeith,Ajay Macharouthu,John T. O'Brien,Peter Passmore,Bart Sheehan,Edmund Juszczak,Cornelius Katona,Robert Kerrin Hills,Martin Knapp,Clive Ballard,Richard G. Brown,Sube Banerjee,Caroline Onions,Mary Griffin,Jessica Adams,Richard Gray,Tony Johnson,Peter Bentham,Patrick P. J. Phillips +32 more
TL;DR: In patients with moderate or severe Alzheimer's disease, continued treatment with donepezil was associated with cognitive benefits that exceeded the minimum clinically important difference and with significant functional benefits over the course of 12 months.
Journal ArticleDOI
Current and future treatments for Alzheimer's disease.
TL;DR: Current symptomatic treatments and new potential disease-modifying therapies for AD that are currently being studied in phase I–III trials are discussed.
Journal ArticleDOI
Screening for Cognitive Impairment in Older Adults: A Systematic Review for the U.S. Preventive Services Task Force
TL;DR: Brief instruments to screen for cognitive impairment can adequately detect dementia, but there is no empirical evidence that screening improves decision making.
Journal ArticleDOI
Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology
John T. O'Brien,Clive Holmes,Matthew Jones,Roy W. Jones,Gill Livingston,Ian G. McKeith,Peter Mittler,Peter Passmore,Craig W. Ritchie,Louise Robinson,Elizabeth L Sampson,John-Paul Taylor,Alan J. Thomas,Alistair Burns +13 more
TL;DR: The British Association for Psychopharmacology coordinated a meeting of experts to review and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs, with the consensus statement focusing on medication.
References
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A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation☆
TL;DR: The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death fromComorbid disease for use in longitudinal studies and further work in larger populations is still required to refine the approach.
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Constructing a Control Group Using Multivariate Matched Sampling Methods That Incorporate the Propensity Score
TL;DR: This article used multivariate matching methods in an observational study of the effects of prenatal exposure to barbiturates on subsequent psychological development, using the propensity score as a distinct matching variable.
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Propensity score methods for bias reduction in the comparison of a treatment to a non‐randomized control group
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Global prevalence of dementia: a Delphi consensus study
Cleusa P. Ferri,Martin Prince,Carol Brayne,Henry Brodaty,Laura Fratiglioni,Mary Ganguli,Kathleen S. Hall,Kazuo Hasegawa,Hugh C. Hendrie,Yueqin Huang,Anthony F. Jorm,Colin Mathers,Paulo Rossi Menezes,Elizabeth Rimmer,Marcia Scazufca +14 more
TL;DR: Detailed estimates of dementia prevalence for each world region are believed to constitute the best currently available basis for policymaking, planning, and allocation of health and welfare resources.
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Variable Selection for Propensity Score Models
M. Alan Brookhart,Sebastian Schneeweiss,Kenneth J. Rothman,Kenneth J. Rothman,Robert J. Glynn,Jerry Avorn,Til Stürmer +6 more
TL;DR: The authors present the results of two simulation studies designed to help epidemiologists gain insight into the variable selection problem in a PS analysis, which suggest that standard model-building tools designed to create good predictive models of the exposure will not always lead to optimal PS models, particularly in small studies.
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Review: Cholinesterase inhibitors but not memantine increase syncope in older adults with mild cognitive impairment or dementia
Review: Cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment
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