Journal ArticleDOI
Synthesis and Antibacterial Activity Studies of 8,9‐Dihydro [7h] Benzo 1,2,4‐Oxadiazoles and its Coumarin Derivatives
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TLDR
In this paper, the synthesis, characterization, and antibacterial active studies of 12 coumarin derivatives were described by using 4-carbonyl chloride with 1,2-dichloroethane as a solvent, in moderate to good yields.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2017-09-18. It has received 11 citations till now. The article focuses on the topics: Antibacterial activity.read more
Citations
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Journal ArticleDOI
Coumarin-containing hybrids and their antibacterial activities.
TL;DR: This review outlines the advances in coumarin‐containing hybrids with antibacterial potential in the recent 5 years and the structure–activity relationships are also discussed.
Journal ArticleDOI
Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis.
Srihari Konduri,Jyothi Prashanth,Vagolu Siva Krishna,Dharmarajan Sriram,J. N. Behera,Dionicio Siegel,Koya Prabhakara Rao +6 more
TL;DR: A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculosis, designed to target MurB disrupting the biosynthesis of the peptidoglycan and exert antiproliferative effects.
Journal ArticleDOI
Design and Synthesis of "Chloropicolinate Amides and Urea Derivatives" as Novel Inhibitors for Mycobacterium tuberculosis.
Srihari Konduri,Dodda Bhargavi,Jyothi Prashanth,Vagolu Siva Krishna,Dharmarajan Sriram,Koya Prabhakara Rao +5 more
TL;DR: A series of 30 diamino phenyl chloropicolinate fettered carboxamides, urea, and thiourea derivatives were synthesized by coupling of methyl 4-amino-6-(2-aminophenyl)-3-chloropyridine-2-carboxylate with different acid chlorides and urea derivatives, respectively as mentioned in this paper.
Journal ArticleDOI
Sacubitril-Based Urea and Thiourea Derivatives as Novel Inhibitors for Anti-Tubercular against Dormant Tuberculosis
Srihari Konduri,Vinay Pogaku,Jyothi Prashanth,Vagolu Siva Krishna,Dharmarajan Sriram,Srinivas Basavoju,J. N. Behera,Koya Prabhakara Rao +7 more
References
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Journal ArticleDOI
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.
Nesrin Gökhan-Kelekçi,Samiye Yabanoglu,Esra Küpeli,Umut Salgın,Özen Özgen,Gulberk Ucar,Erdem Yesilada,Engin Kendi,Akgül Yeşilada,A. Altan Bilgin +9 more
TL;DR: A novel series of 1-thiocarbamoyl-3-substituted phenyl-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole derivatives as promising MAO-B inhibitors was synthesized and investigated for the ability to inhibit selectively the activity of the A and B isoforms of monoamine oxidation.
Journal ArticleDOI
Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.
TL;DR: Enantiopure heterocyclic Boc-protected Phe-Gly dipeptidomimetics containing 1,3, 4-oxadiazole, 1,2,4-ox adenosine ring systems have been synthesized as building blocks in the synthesis of pseudopeptides.
Journal ArticleDOI
Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin.
Mahantesha Basanagouda,Kalegowda Shivashankar,Manohar V. Kulkarni,Vijaykumar P. Rasal,Harishchandra Patel,Sumit S. Mutha,Ashwini A. Mohite +6 more
TL;DR: A series of new and novel coumarin-6-sulfonamides with a free C4-azidomethyl group have been synthesized as antimicrobials as well as screened for their in vitro anti-bacterial and anti-fungal activities.
Journal ArticleDOI
Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide.
TL;DR: The authors' aliphatic sulfonamides have highest powerful antibacterial activity for Gram-negative bacteria than Gram-positive bacteria and antib bacterial activity decreases as the length of the carbon chain increases.
Journal ArticleDOI
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.
Leslie J. Street,R. Baker,T. Book,Kneen Clare O,Angus Murray Macleod,Kevin John Merchant,Graham Andrew Showell,John Saunders,Richard H. Herbert,Stephen B. Freedman +9 more
TL;DR: The synthesis and biochemical evaluation of novel 1,2,4-oxadiazole-based muscarinic agonists which can readily penetrate into the CNS is reported and efficacy and affinity are influenced by the geometry between the cationic head.
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