Journal ArticleDOI
Synthesis and Applications of End-Labeled Neoglycopolymers
TLDR
Neoglycopolymers that vary in length and contain a single fluorescent reporter group were synthesized using ring-opening metathesis polymerization (ROMP) and the data reveal that these multivalent ligands interact with multiple copies of L-selectin.About:
This article is published in Organic Letters.The article was published on 2002-06-11. It has received 99 citations till now.read more
Citations
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Synthetic Multivalent Ligands as Probes of Signal Transduction
TL;DR: This Review focuses on the use of synthetic multivalent ligands to characterize receptor function through chemical synthesis to address the role of receptor assembly in signal transduction.
Journal ArticleDOI
Peptide/protein – polymer conjugates: synthetic strategies and design concepts
Marc A. Gauthier,Harm-Anton Klok +1 more
TL;DR: An overview of the use of chemoselective reactions such as Heck, Sonogashira and Suzuki coupling, Diels-Alder cycloaddition, Click chemistry, Staudinger ligation, Michael's addition, reductive alkylation and oxime/hydrazone chemistry for the convergent synthesis of peptide/protein-polymer conjugates is given.
Journal ArticleDOI
Telechelic polymers by living and controlled/living polymerization methods
TL;DR: In this paper, the authors describe the general techniques for the preparation of telechelic polymers by living and controlled/living polymerization methods, including atom transfer radical polymerization, nitroxide mediated radical polymerisation, reversible addition-fragmentation chain transfer polymerization and iniferters.
Journal ArticleDOI
Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules
Anindita Das,Patrick Theato +1 more
Journal ArticleDOI
Glycopolymer probes of signal transduction
TL;DR: This review provides examples in which glycopolymers have been used to effect carbohydrate- mediated signal transduction and illustrates how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signalTransduction.
References
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Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
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Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
TL;DR: Polyvalent interactions can be collectively much stronger than corresponding monovalent interactions, and they can provide the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available inmonovalent systems.
Journal ArticleDOI
The Development of L2X2RuCHR Olefin Metathesis Catalysts: An Organometallic Success Story
Tina M. Trnka,Robert H. Grubbs +1 more
TL;DR: The discussion includes an analysis of trends in catalyst activity, a description of catalysts coordinated with N-heterocyclic carbene ligands, and an overview of ongoing work to improve the activity, stability, and selectivity of this family of L2X2Ru=CHR complexes.
Journal ArticleDOI
Intracellular functions of N-linked glycans.
Ari Helenius,and Markus Aebi +1 more
TL;DR: The division of synthesis and processing between the ER and the Golgi complex represents an evolutionary adaptation that allows efficient exploitation of the potential of oligosaccharides.