Journal ArticleDOI
Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: stimulation of guanylate cyclase and inhibition of platelet aggregation.
TLDR
It is demonstrated that rat mast cells release a factor with the same pharmacological profile as NO, and that this NO-like factor is derived from L-arginine.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1990-06-15. It has received 145 citations till now. The article focuses on the topics: Mast cell & Nitric oxide.read more
Citations
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Journal ArticleDOI
Mammalian nitric oxide synthases.
TL;DR: This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions.
Journal ArticleDOI
Endogenous nitric oxide: physiology, pathology and clinical relevance.
Salvador Moncada,E. A. Higgs +1 more
TL;DR: The formation of nitric oxide from the amino acid L-arginine not only explains the biological properties of the so-called endothelium-derived relaxing factor but also accounts for the stimulation of the soluble guanylate cyclase in a number of tissues such as the platelet and the brain.
Journal ArticleDOI
The 1991 Ulf von Euler Lecture:The l-arginine: nitric oxide pathway
TL;DR: ‘The authors must always guard the liberties of the mind and remember that some degree of heresy is often a sign of health in spiritual life.
Journal ArticleDOI
Role of nitric oxide in gastrointestinal and hepatic function and disease
TL;DR: Recent evidence indicates that no functions as a mediator, a messenger, or a regulator of cell function in a number of physiological systems and pathophysiological states and speculates on potential clinical implications.
Book ChapterDOI
Mammalian nitric oxide synthases.
TL;DR: This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions.
References
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Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
TL;DR: NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator.
Journal ArticleDOI
Vascular endothelial cells synthesize nitric oxide from L-arginine.
TL;DR: It is demonstrated that NO can be synthesized from L-arginine by porcine aortic endothelial cells in culture and the strict substrate specificity of this reaction suggests that L- arginine is the precursor for NO synthesis in vascular endothelium cells.
Journal ArticleDOI
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
TL;DR: It is demonstrated that EDRF is protected from breakdown by superoxide dismutase (SOD) and Cu2+, but not by catalase, and is inactivated by Fe2+.
Journal ArticleDOI
The aggregation of blood platelets
G. V. R. Born,M. J. Cross +1 more
TL;DR: A method by which the aggregation of platelets may be followed quantitatively is described, and results obtained with the method are described.