Journal ArticleDOI
Synthesis of Bioactive 4-Oxo-4H-Chromenes Bearing Heterocyclic Systems from Hydrazonecarbodithioic Acid and Thiocarbohydrazone
TLDR
In this article, the synthesis of 4-oxo-4H-chromene-3-carboxaldehydes with acid hydrazine-carbodithioic acid and/or thiocarbohydrazide has been studied.Abstract:
Condensation 4-oxo-4H-chromene-3-carboxaldehydes (1a,b) with acid hydrazine-carbodithioic acid and/or thiocarbohydrazide afforded hydrazonecarbodithioic acid 2, monothiocarbohydrazone 3a,b and bisthiocarbohydrazone 4, respectively. Heterocyclization of 2–4 via reaction with oxygen, sulfur and/or halogen reagents in different media yielded pyridazinethione 5; 1,3-thiazoles 7; pyrazoles 9–12; 1,2,4-thiadiazoles 8,13,14, and 23; 1,2,4-triazolethiones 15–17; 1,2,4-triazinethiones 18–22; imidazolethione 24 and pyrimidinethione 25 derivatives. Antifungal activity was screened for some the new synthesized compounds. Formulations of all products have been deduced by elemental analysis and spectral data (IR, 1H NMR and Mass spectroscopy).read more
Citations
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Journal ArticleDOI
Utility of thiocarbohydrazide in heterocyclic synthesis
TL;DR: In this paper, the synthesis and properties of thiocarbohydrazide and its utility as a building block for the synthesis of heterocyclic systems with pharmacological interest are described.
Journal ArticleDOI
Studies on the Chemical Reactivity of 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde Towards Some Nitrogen Nucleophilic Reagents
TL;DR: In this paper, the chemical reactivity of 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde was studied towards some nitrogen nucleophilic reagents such as heterocyclic amines under different reaction conditions.
Journal ArticleDOI
Co(II), Ni(II), Cu(II) and Cd(II)-thiocarbonohydrazone complexes: spectroscopic, DFT, thermal, and electrical conductivity studies
R. Fouad,Ibrahim A. Shaaban,Ibrahim A. Shaaban,Tarik E. Ali,Tarik E. Ali,Mohammed A. Assiri,S. S. Shenouda +6 more
TL;DR: In this paper, the structural and spectroscopic properties of MCMT and its metal complexes have been investigated using the DFT-B3LYP method, which showed that MCMT behaves as a neutral NS bidentate moiety that forms octahedral complexes with general formula [M(MCMT)2Cl(OH2)]Cl·XH2O (M = Cu2+; (X = ½), Ni2+, Co2+, Co2+, [Cd[Cd
Journal ArticleDOI
Synthesis of Biologically Active 4-Oxo-4H-Chromene Derivatives Containing Sulfur-Nitrogen Heterocycles
TL;DR: The synthesis of 4-oxo-4H-chromenes containing sulfur-nitrogen heterocyclic rings as well as their biological activities are reviewed in this article, where the synthesis process is described in detail.
Journal ArticleDOI
Design and Synthesis, Antimicrobial Activities of 1,2,4-Triazine Derivatives as Representation of a New Hetrocyclic System
TL;DR: The antimicrobial effects including antibacterial and antifungal activities, based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration(MFC) values the authors reported.
References
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Journal ArticleDOI
Synthesis, antimicrobial activity and bleaching effect of some reaction products of 4-oxo-4H-benzopyran-3-carboxaldehydes with aminobenzothiazoles and hydrazides
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Journal ArticleDOI
Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities
TL;DR: The antibacterial, antifungal and antimycobacterial activities, together with those of known intermediate 1,4-disubstituted thiosemicarbazides, were reported.
Journal ArticleDOI
Synthesis of Heterobicyclic Nitrogen Systems Bearing a 1,2,4-Triazine Moiety as Anticancer Drugs: Part IV
TL;DR: Some new isolated and fused heterobicyclic nitrogen systems have been synthesized via treatment of 4-amino-6-styryl-3-thioxo-1, 2,4-triazin-5(2,4H)ones with cyclic and acyclic oxygen and nitrogen compounds as mentioned in this paper.
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