Journal ArticleDOI
Synthesis of certain pyrazolo[3,4-d]pyrimidin-3-one nucleosides
Jack D. Anderson,Howard B. Cottam,Steven B. Larson,L. Dee Nord,G. R. Revankar,Roland K. Robins +5 more
TLDR
The pyrazolo[3,4-d]pyrimidin-3-one congeners of guanosine, adenosine and inosine is described in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-02-01. It has received 54 citations till now. The article focuses on the topics: Adenine analog & Bicyclic molecule.read more
Citations
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Journal ArticleDOI
Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives.
Aymn E. Rashad,Mohamed I. Hegab,Randa E. Abdel-Megeid,Jehan A. Micky,Farouk M. E. Abdel-Megeid +4 more
TL;DR: The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1).
Journal ArticleDOI
Medicinal attributes of pyrazolo[3,4-d]pyrimidines: a review.
Monika Chauhan,Raj Kumar +1 more
TL;DR: The present manuscript to the best of the authors' knowledge is the first compilation on synthesis and medicinal aspects including structure-activity relationships of pyrazolo[3,4-d]pyrimidines reported to date.
Journal ArticleDOI
Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles.
Wedad M. Al-Adiwish,Mohamed Ibrahim Mohamed Tahir,A. Siti-Noor-Adnalizawati,Siti Farah Hashim,Nazlina Ibrahim,Wan Ahmad Yaacob +5 more
TL;DR: New 5-aminopyrazoles 2a-c were prepared in high yields from the reaction of known α,α-dicyanoketene-N,S-acetal with hydrazine hydrate under reflux in ethanol, and the antibacterial activity and cytotoxicity against Vero cells of several selected compounds are reported.
Journal ArticleDOI
Synthesis of functionalized tetrasubstituted pyrazolyl heterocycles--a review.
Sureshbabu Dadiboyena,Adel Nefzi +1 more
TL;DR: The current review summarized recent advances in the synthesis of tetrasubstituted pyrazoles represents key structural motifs in heterocyclic chemistry and are present in a large number of biologically active molecules relevant to the pharmaceutical and agrochemical industries.
Journal ArticleDOI
Catalytic synthesis of 6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4[5H]-ones by heteropolyacid: H14[NaP5W30O110] and H3PW12O40
TL;DR: In the presence of heteropoly acids, H3PW12O40 and H14[NaP5W30MoO110] gave derivatives of 6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4[5H]-ones 4.
References
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Journal ArticleDOI
Coherent X‐Ray Scattering for the Hydrogen Atom in the Hydrogen Molecule
TL;DR: In this paper, the x-ray form factors for a bonded hydrogen in the hydrogen molecule have been calculated for a spherical approximation to the bonded atom, and the corresponding complex scattering factors have also been calculated.
ReportDOI
OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations
TL;DR: A computer program is described for drawing crystal structure illustrations using a mechanical plotter that can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns.
Journal ArticleDOI
Synthetic methods and reactions. 62. Transformations with chlorotrimethylsilane/sodium iodide, a convenient in situ iodotrimethylsilane reagent
TL;DR: In this paper, a mixture of chlorotrimethylsilane/sodium iodide in acetonitrile is found to be a better reagent than iodotrim methylsilane for the cleavage of esters, lactones, carbamates, and ethers.
Journal ArticleDOI
Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylases.
TL;DR: Of the substrates tested, the most potent stabilizers of Urd Pases, dThd Pase, and PN Pase were uridine, 2'-deoxyribose 1-phosphate, and ribose1-ph phosphate, respectively.