Journal ArticleDOI
Synthesis of di- and trihydroxy proline derivatives from D-glycals: Application in the synthesis of polysubstituted pyrrolizidines and bioactive 1C-aryl/alkyl pyrrolidines.
Reads0
Chats0
TLDR
The stereoselective synthesis of biologically active 1C-aryl/alkyl pyrrolidines through double reductive amination of a variety of D-glucal derived diketones with p-methoxybenzylamine is reported on.About:
This article is published in Carbohydrate Research.The article was published on 2019-03-01. It has received 5 citations till now. The article focuses on the topics: Reductive amination & Cycloaddition.read more
Citations
More filters
Journal ArticleDOI
Iminosugars as glycosyltransferase inhibitors
Irene Conforti,Alberto Marra +1 more
TL;DR: The synthesis and biological properties of all the iminosugars assayed to date as glycosyltransferase inhibitors are reviewed in the present article as discussed by the authors, where they are also used as inhibitors of the enzymes responsible for the synthesis of oligosaccharides and glycoconjugates.
Journal ArticleDOI
Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications
TL;DR: This review comprehensively summarized the therapeutic effects and related mechanisms of GL and its derivatives in managing blood glucose levels and treating T2DM and its complications and recent progress in the development of potential drugs targeting T2 DM.
Journal ArticleDOI
Heterocyclic Compounds as Dipeptidyl Peptidase-IV Inhibitors with Special Emphasis on Oxadiazoles as Potent Anti-Diabetic Agents
Badrud Duza Mohammad,Mirza Shahed Baig,Neeraj Bhandari,Falak A. Siddiqui,Sharuk L. Khan,Zubair Ahmad,Farhat Khan,Priti Tagde,Philippe Jeandet +8 more
TL;DR: It was observed that oxadiazole fusion with benzothiazole, 5-(2,5,2-trifluoroethoxy) phenyl, β-homophenylalanine, 2-methyl-2-{5-(4-chlorophenyl), diamine-bridged bis-coumarinyl, 5-aryl-2-(6′-nitrobenzofuran-2′-yl), nitrobenZofuran, and/or
Journal ArticleDOI
Recent Advances in the Synthesis and Application of C -2-Formyl Glycals
TL;DR: A literature survey on the synthesis of C-2-formyl-glycals can be found in this article , which further highlights the importance of these molecules for many medicinal, supramolecular, biological, organic as well as material chemistry-based molecules.
Journal ArticleDOI
Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance
TL;DR: This comprehensive review comprehensively summarized the different synthetic approaches to the preparation of multivalent pyrrolidine clusters, from total synthesis of divalent iminosugars to complex architectures bearing twelve p Pyrrolidine motifs.
References
More filters
Journal ArticleDOI
Biological Roles of Glycans
TL;DR: It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences, as they are no different from other major macromolecular building blocks of life, simply more rapidly evolving and complex.
Journal Article
Chemical glycobiology : Carbohydrates and glycobiology
TL;DR: Chemical tools have proven indispensable for studies in glycobiology and chemical approaches are contributing great insight into the myriad biological functions of oligosaccharides.
Journal ArticleDOI
Synthesis and medical applications of oligosaccharides
TL;DR: Synthetic tools and high-throughput experiments such as carbohydrate arrays are beginning to affect biological research, and are being applied to the development of carbohydrate-based diagnostics, vaccines and therapeutics.
Journal ArticleDOI
Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research
TL;DR: Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological research and as lead compounds for drug and vaccine discovery, and the power of carbohydrate chemistry is highlighted by an ability to synthesize glycoproteins.
Journal ArticleDOI
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Bruce D. Walker,Mark Kowalski,Wei Chun Goh,Karen Kozarsky,Monty Krieger,Craig A. Rosen,Larry R. Rohrschneider,William A. Haseltine,Joseph Sodroski +8 more
TL;DR: The antiviral effects of castanospermine may be due to modifications of the envelope glycoprotein that affect the ability of the virus to enter cells after attachment to the CD4 cell receptor.