Journal ArticleDOI
Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.
TLDR
Eel-calcitonin and its [Asu1,7]-analog, deamino-dicarba-Analog, were synthesized by the conventional solution method and showed a potency comparable to that of the natural hormone isolated from eel.Abstract:
Eel-calcitonin and its [Asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.read more
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Synthesis of a Glycopeptide Containing Oligosaccharides: Chemoenzymatic Synthesis of Eel Calcitonin Analogues Having Natural N-Linked Oligosaccharides
Mamoru Mizuno,Katsuji Haneda,Reiko Iguchi,Ikuyo Muramoto,Toru Kawakami,Saburo Aimoto,Kenji Yamamoto,Toshiyuki Inazu +7 more
TL;DR: A novel chemoenzymatic synthesis of eel calcitonin (eCT) glycopeptide analogues having natural N-linked oligosaccharides, such as a disialo biantennary complex-type, an asialo complex- type, and a high-mannose type as model compounds for glycoprotein synthesis are described.
Journal Article
Calcitonin and 1,25-Dihydroxyvitamin D3 Receptors in Human Breast Cancer Cell Lines
David M. Findlay,V. P. Michelangeli,John A. Eisman,R. J. Frampton,Jane M. Moseley,I. MacIntyre,R. Whitehead,Thomas J. Martin +7 more
TL;DR: Breast cancer cell lines provide a useful source of 1,25-dihydroxyvitamin D3 receptors and their coexistence with a calcitonin receptor and biological response in some breast cancers offers the opportunity to investigate new aspects of breast cancer endocrinology.
Journal ArticleDOI
The Calcitonin Gene Peptides: Biology and Clinical Relevance
TL;DR: The molecular genetics, structure, and function of the calcitonin-gene peptides as analyzed in the laboratory are reviewed and more recent clinical studies relating to disorders and therapeutics are focused on.
Journal ArticleDOI
Parenteral calcitonin for metabolic bone disease associated with primary biliary cirrhosis
Andrea Crosignani,Pier Maria Battezzati,Walter Albisetti,Giuseppe Grandinetti,Luca Pietrogrande,A. Biffi,Massimo Zuin,Mauro Podda +7 more
TL;DR: It is indicated that parenterally administered calcitonin for 6 mo is ineffective in halting bone loss in patients with primary biliary cirrhosis—associated metabolic bone disease, whereas calcium supplementation may have a transient beneficial effect.
Journal ArticleDOI
The Activity of Peptides of the Calcitonin Family in Bone
TL;DR: Surprisingly, studies in genetically modified mice have demonstrated that the physiological role of calcitonin appears to be the inhibition of osteoblast activity and bone turnover, whereas amylin inhibits osteoclast activity.
References
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Amino acid sequence of salmon ultimobranchial calcitonin
TL;DR: Although the sequence of the salmon hormone differs considerably from that of the porcine, bovine and human calcitonins, the four hormones are homologous in 9 of 32 positions and makes it of particular interest for future structure function studies.
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A new method for releasing oxytocin from fully-protected nona-peptides using anhydrous hydrogen fluoride.
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A biological assay for calcitonin.
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Isolation and Chemical Properties of Two Calcitonins from Salmon Ultimobranchial Glands
TL;DR: Both forms of the salmon hormone have the highest specific biological activity of any natural calcitonin thus far described and indicate that it may be useful in the study of structure-function relationships in the calcitonins.
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Struktur-Wirkungsbeziehungen beim menschlichen Calcitonin. III. Die biologische Aktivität verkürzter oder an den Kettenenden modifizierter, synthetischer analoger
TL;DR: Assays of 8 synthetic analogues of human calcitonin in rats showed that their hypocalcaemic activity was drastically reduced by deletion of the C-terminal amide group, chain-shortening or opening of the disulphide ring, but unaffected or enhanced by modification of the N-Terminal amino group.