Journal ArticleDOI
Synthetic activities during spermatogenesis in the mouse, rna and protein.
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TLDR
A number of evidences suggest that this “arginine-rich” spermatid histone is effectively synthesized within the nucleus, although the alternative interpretation of a cytoplasmic synthesis followed by transfer of the newly synthesized histone into the nucleus cannot be actually rejected.About:
This article is published in Experimental Cell Research.The article was published on 1965-08-01. It has received 407 citations till now. The article focuses on the topics: Spermiogenesis & Prophase.read more
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The biology of infertility: research advances and clinical challenges
Martin M. Matzuk,Dolores J. Lamb +1 more
TL;DR: The past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility, but translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples.
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H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis
Oscar Fernandez-Capetillo,Shantha K. Mahadevaiah,Arkady Celeste,Peter J. Romanienko,R. Daniel Camerini-Otero,William M. Bonner,Katia Manova,Paul S. Burgoyne,André Nussenzweig +8 more
TL;DR: It is shown that the X and Y chromosomes of histone H2AX-deficient spermatocytes fail to condense to form a sex body, do not initiate MSCI, and exhibit severe defects in meiotic pairing.
Journal ArticleDOI
BRCA1, Histone H2AX Phosphorylation, and Male Meiotic Sex Chromosome Inactivation
James M. A. Turner,Olga Aprelikova,Xiaoling Xu,Rui-Hong Wang,Sangsoo Kim,Gadisetti V.R. Chandramouli,J. Carl Barrett,Paul S. Burgoyne,Chu-Xia Deng +8 more
TL;DR: It is shown that the kinase ATR localizes to XY chromatin at the onset of MSCI and that this localization is disrupted in mice with a mutant form of the tumor suppressor protein BRCA1, and compelling evidence is provided that it is ATR that phosphorylates H2AX and triggers MSCi.
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Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes
TL;DR: The proliferation and meiotic phase whereby spermatogonia undergo several mitotic divisions to form sperMatocytes that undergo two meiotic divisions to forms haploid sperMATids is discussed.
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Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Godfried W. van der Heijden,Jürgen Dieker,Alwin A.H.A. Derijck,Sylviane Muller,Jo H. M. Berden,Didi D.M. Braat,Johan van der Vlag,Peter Boer +7 more
TL;DR: The male, in contrast to female G1 chromatin, is uniform and contains predominantly hist one H3.3 as histone H3 variant, while the maternal genome is arrested in meiotic metaphase II.
References
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Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
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Definition of the Stages of the Cycle of the Seminiferous Epithelium in the Rat
C. P. Leblond,Yves Clermont +1 more
TL;DR: In the present work, the cellular associations were defined by the stage of development of the spermatids, which themselves were characterized by their staining reaction to the “periodic acid-Schiff” technique (hereafter referred to as PAFSA).
Journal ArticleDOI
A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal.
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