T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
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TLDR
Whether Th cell pathogenicity can be defined solely based on their cytokine profiles and whether rigid definition of a Th cell subset by its cytokine profile is helpful are discussed.About:
This article is published in Cytokine.The article was published on 2015-07-01 and is currently open access. It has received 792 citations till now. The article focuses on the topics: Proinflammatory cytokine & Cytokine.read more
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Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?
Feifei Qiu,Chun-Ling Liang,Huazhen Liu,Yu-Qun Zeng,Shaozhen Hou,Song Huang,Xiao-Ping Lai,Zhenhua Dai +7 more
TL;DR: This work aims to systematically and objectively review the influence of smoking on major components of both innate and adaptive immune cells, and summarize cellular and molecular mechanisms underlying effects of cigarette smoking on the immune system.
Journal ArticleDOI
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy
Vita M. Golubovskaya,Lijun Wu +1 more
TL;DR: Next-generation CAR-T immunotherapy can be improved, based on knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more activeCAR-T cells against tumors.
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Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review
TL;DR: It is demonstrated how the imbalance between oxidants and antioxidants resulting from exposure to tobacco smoke leads to oxidative stress, increased mucosal inflammation, and increased expression of inflammatory cytokines (such as interleukin (IL)-8, IL-6 and tumor necrosis factor α ([TNF]-α).
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Effects of Omega-3 Fatty Acids on Immune Cells.
TL;DR: The latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms are described.
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Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
Valerio Chiurchiù,Alessandro Leuti,Jesmond Dalli,Anders Jacobsson,Luca Battistini,Mauro Maccarrone,Charles N. Serhan +6 more
TL;DR: D-series resolvins and maresin 1 modulate adaptive immune responses in human peripheral blood lymphocytes and reduce cytokine production by activated CD8+ T cells and CD4+ T helper 1 (TH1) and TH17 cells but do not modulate T cell inhibitory receptors or abrogate their capacity to proliferate.
References
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Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
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Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells
TL;DR: It is reported that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development and function and ectopic expression ofFoxp3 confers suppressor function on peripheral CD4-CD25− T cells.
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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
TL;DR: The authors showed that CD4+CD25+ cells contribute to maintaining self-tolerance by downregulating immune response to self and non-self Ags in an Ag-nonspecific manner, presumably at the T cell activation stage.
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.