Journal ArticleDOI
Taxol Determination from Pestalotiopsis pauciseta, a Fungal Endophyte of a Medicinal Plant
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TLDR
This fungal taxol also had strong anticancer activity against some cancer cells tested by Apoptotic assay and it is indicated that with the increase of taxol concentration from 0.005-0.05 micromol/L, taxol induced increased cell death through apoptosis.About:
This article is published in Chinese Journal of Biotechnology.The article was published on 2008-08-01. It has received 64 citations till now.read more
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Anticancer compounds derived from fungal endophytes: their importance and future challenges.
TL;DR: This is a review of anticancer agents isolated from endophytic fungi from 1990–2010, based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines.
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A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review.
TL;DR: This paper will focus on the increasing knowledge of relationships between endophytic fungi and medicinal plants through reviewing of published research data obtained from the last 30 years and indicates that the distribution and population structure of endophytes can be considerably affected by factors, such as the genetic background, age, and environmental conditions of their hosts.
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Plant-derived bioactive compounds produced by endophytic fungi.
TL;DR: This review mainly deals with the research progress on endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin, and diosgenin.
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Pestalotiopsis—morphology, phylogeny, biochemistry and diversity
Sajeewa S. N. Maharachchikumbura,Sajeewa S. N. Maharachchikumbura,Liang-Dong Guo,Ekachai Chukeatirote,Ali H. Bahkali,Kevin D. Hyde,Kevin D. Hyde +6 more
TL;DR: It is concluded that the large number of described species has resulted from introductions based on host association and that many of these are probably not good biological species and researchers should refrain from providing the exact name of species.
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A review: recent advances and future prospects of taxol-producing endophytic fungi
TL;DR: Recent advances in taxol-producing endophytic fungi, both in China and abroad, in the following areas are summarized: isolation and identification of endophytics fungi types, extraction and detection methods ofendophytic taxol in plants, and improved efficiency of the extraction process.
References
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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
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Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
TL;DR: Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
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Endophytes as sources of bioactive products.
TL;DR: Endophytes are a novel source of potentially useful medicinal compounds and an intensive search for newer and more effective agents to deal with health problems caused by various cancers, drug-resistant bacteria, parasitic protozoans, and fungi is under way.
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Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana.
TL;DR: Pestalotiopsis microspora was isolated from the inner bark of a small limb of Himalayan yew, and was shown to produce taxol in mycelial culture, and spectroscopic and chromatographic comparisons with authentic taxol were identified.
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Ecology, metabolite production, and substrate utilization in endophytic fungi.
TL;DR: The production of growth promoting factors and of metabolites useful in the pharmaceutical and agricultural industry is widespread among endophytic fungi, and their usefulness in agricultural and pharmaceutical research is briefly discussed.