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Open AccessProceedings ArticleDOI

Testing of droplet-based microelectrofluidic systems

Fei Su, +2 more
- Vol. 1, pp 1192-1200
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TLDR
This paper presents a costeffective concurrent test methodology for droplet-based microelectrofluidic systems, presents a classification of catastrophic and parametric faults in such systems and shows how faults can be detected by electrostatically controlling and tracking droplet motion.
Abstract
Composite microsystems that integrate mechanical and fluidic components are fast emerging as the next generation of system-on-chip designs. As these systems become widespread in safety-critical biomedical applications, dependability emerges as a critical performance parameter. In this paper, we present a costeffective concurrent test methodology for droplet-based microelectrofluidic systems. We present a classification of catastrophic and parametric faults in such systems and show how faults can be detected by electrostatically controlling and tracking droplet motion. We then present tolerance analysis based on Monte-Carlo simulations to characterize the impact of parameter variations on system performance. To the best of our knowledge, this constitutes the first attempt to define a fault model and to develop a test methodology for droplet-based microelectrofluidic systems.

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Citations
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Patent

Method of growing cells on a droplet actuator

TL;DR: In this article, a method of growing cells on a droplet actuator is described, where the droplet is used to provide a medium for the cells to grow in the cell culture medium on the actuator.
Proceedings Article

Towards design-for-testability for digital microfluidics

TL;DR: In this paper, a testability-aware bioassay protocol is proposed to ensure a high level of testability, defined as the percentage of the electrodes or functional units on the synthesized chip that can be effectively tested.
Book ChapterDOI

Multiple Fault Identification and Diagnosis in Cross-Referencing Digital Microfluidic Biochips

TL;DR: In this paper, a detailed offline multiple fault diagnosis has been presented in conjunction with a detection technique for cross-referencing digital microfluidic biochips, which can detect multiple faults anywhere within a cross-reference chip that satisfies the electrode interference challenge as well as dynamic fluidic constraints.
References
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TL;DR: A device was developed that uses microfabricated fluidic channels, heaters, temperature sensors, and fluorescence detectors to analyze nanoliter-size DNA samples to facilitate the use of DNA analysis in applications such as rapid medical diagnostics and point-of-use agricultural testing.
Journal ArticleDOI

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TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.

Microfluidic Large Scale Integration

TL;DR: High-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers are developed to construct the microfluidity analog of a comparator array and a microfluidsic memory storage device whose behavior resembles random-access memory.
Journal ArticleDOI

Review of statistical approaches to tolerance analysis

TL;DR: The technique of applying statistical methods to tolerance analysis of mechanical assemblies and the application of these methods to solid modelling systems and to the geometric tolerancing standard are described.
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