Journal ArticleDOI
The absolute configuration of δ1-tetrahydrocannabinol, the major active constituent of hashish.
Raphael Mechoulam,Yehiel Gaoni +1 more
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This article is published in Tetrahedron Letters.The article was published on 1967-01-01. It has received 189 citations till now. The article focuses on the topics: Hashish.read more
Citations
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Allyn C. Howlett,Francis Barth,Tom I. Bonner,Guy A. Cabral,Pierre Casellas,William A. Devane,Christian C. Felder,Miles Herkenham,Ken Mackie,Billy R. Martin,Raphael Mechoulam,Roger G. Pertwee +11 more
TL;DR: It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking.
Journal ArticleDOI
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
TL;DR: A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Journal ArticleDOI
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
Tiziana Bisogno,Lumir Hanus,Luciano De Petrocellis,Susanna Tchilibon,Datta E. Ponde,Ines Brandi,Aniello Schiano Moriello,John B. Davis,Raphael Mechoulam,Vincenzo Di Marzo +9 more
TL;DR: Results suggest that VR1 receptors, or increased levels of endogenous AEA, might mediate some of the pharmacological effects of CBD and its analogues, and (−)‐5′‐DMH‐CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent.
Journal ArticleDOI
Chemical constituents of marijuana: The complex mixture of natural cannabinoids
Mahmoud A. ElSohly,Desmond Slade +1 more
TL;DR: The chemical constituents of the plant are discussed with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties.
Journal ArticleDOI
Cannabinoid physiology and pharmacology: 30 years of progress
Allyn C. Howlett,Allyn C. Howlett,Christopher S. Breivogel,Steven R. Childers,Sam A. Deadwyler,Robert E. Hampson,Linda J. Porrino +6 more
TL;DR: Delta9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through G-protein-coupled receptors, CB1 in the brain, and CB2 in the immune system.
References
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Journal ArticleDOI
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni,Raphael Mechoulam +1 more
TL;DR: In this paper, the extinction coefficients of stilbene, stil bene-, and stilben-2 were determined for tetrahydrofuran, 2-methyltetrahydrlfurfh-fragments, and 1,2-dime thoxye thane.
Journal ArticleDOI
Hashish. I. The Structure of Cannabidiol
Raphael Mechoulam,Shvo Y +1 more
TL;DR: Cannabidiol, one of the major components of hashish, has been shown to possess structure IIIa.
Journal ArticleDOI
A total synthesis of dl-delta-1-tetrahydrocannabinol, the active constituent of hashish.
R Mechoulam,Y Gaoni +1 more
Journal ArticleDOI
Hashish—VII : The isomerization of cannabidiol to tetrahydrocannabinols
Yehiel Gaoni,Raphael Mechoulam +1 more
TL;DR: Adams as mentioned in this paper showed that the physiologically active products obtained by Adams on isomerization of the inactive cannabidiol (Ia) with acids are either Δ 1(6) tetrahydrocannabinol (II) or a mixture of II, Δ 1 tetrahedrocannabinols (IIIa), and the two isomers of 1-ethoxy hexahydricannabinol(VIIIa, VIIIb).
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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni,Raphael Mechoulam +1 more