Journal ArticleDOI
The antigens of Vibrio cholerae involved in the vibriocidal action of antibody and complement.
Sim Hee Neoh,Derrick Rowley +1 more
TLDR
Recent field trials conducted in the Matlab Bazaar area of East Pakistan have indicated that there is a clear correlation between cholera vaccination and infection in any experimental animal.Abstract:
Research in cholera has been greatly hampered by the lack of a clearly correlated model of infection in any experimental animal. The value of various cholera vaccines must, at the moment, be assessed by expensive and prolonged clinical trials in those climatically difficult areas of the world where the disease is endemic. Recent field trials conducted in the Matlab Bazaar area of East Pakistan [1-7] have indicated that there is a clear correlation be-read more
Citations
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Journal ArticleDOI
Further Evidence for Cross-Linking as a Protective Factor in Experimental Cholera: Properties of Antibody Fragments
TL;DR: Results are interpreted as evidence that cross-linking is an important mechanism by which specific antibody protects mucosal surfaces against experimental infection with Vibrio cholerae.
Journal ArticleDOI
Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh.
Daniel T. Leung,Daniel T. Leung,Taher Uddin,Peng Xu,Amena Aktar,Russell A. Johnson,Mohammad Arif Rahman,Mohammad Murshid Alam,Meagan Kelly Bufano,Grace Eckhoff,Ying Wu-Freeman,Yanan Yu,Tania Sultana,Tania Sultana,Farhana Khanam,Amit Saha,Fahima Chowdhury,Ashraf I. Khan,Richelle C. Charles,Regina C. LaRocque,Jason B. Harris,Stephen B. Calderwood,Pavol Kováč,Firdausi Qadri,Edward T. Ryan +24 more
TL;DR: Comparison of polysaccharide antibody responses in children from a region in Bangladesh where cholera is endemic found that infants and young children receiving the vaccine did not mount an IgG, IgA, or IgM antibody response to V. cholerae OSP or LPS, whereas older children showed significant responses.
Book ChapterDOI
Hypothesis: How Licensed Vaccines Confer Protective Immunity
TL;DR: It is theorized that a critical level of serum IgG confers protection against infectious diseases by killing or inactivating the inoculum, and efficacy is reliably predicted by measurement of serum antibodies elicited by vaccines.
Journal ArticleDOI
Isolation of Protective Somatic Antigen from Vibrio cholerae (Ogawa) Ribosomal Preparations
TL;DR: Ribosomal preparations from Vibrio cholerae Ogawa and Inaba are protective immunogens for mice challenged with either serotype and Purification of the solubilized material or of the colloid was unsuccessful.
Journal ArticleDOI
Endotoxins and Bacterial Virulence
TL;DR: The fact that living attenuated bacteria are more efficient promoters of an increased state of resistance to many bacterial infections should not alter this belief in the fundamental importance of phagocytosis.
References
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Journal ArticleDOI
The estimation of the bactericidal power of the blood.
TL;DR: The survival rate, p, of a measured inoculum of Staph.
Journal ArticleDOI
Über die Extraktion von Bakterien mit Phenol/Wasser
TL;DR: In this paper, two einfache Verfahren zur extraktion von Bakterien with Phenol/Wasser angegeben are presented. Butt et al.
Journal Article
The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients.
TL;DR: Vibrio cholerae infection, whether symptomatic or asymptomatic, predominantly occurred in individuals with low titres, and the infection rate fell markedly with age.
Journal ArticleDOI
Sensitivity of Rough Gram-negative Bacteria to the Bactericidal Action of Serum
TL;DR: Three Salmonella minnesota rough mutants were found to be more sensitive to the bactericidal action of antibody and complement than was the parent smooth strain.