Journal ArticleDOI
The antigens of Vibrio cholerae involved in the vibriocidal action of antibody and complement.
Sim Hee Neoh,Derrick Rowley +1 more
TLDR
Recent field trials conducted in the Matlab Bazaar area of East Pakistan have indicated that there is a clear correlation between cholera vaccination and infection in any experimental animal.Abstract:
Research in cholera has been greatly hampered by the lack of a clearly correlated model of infection in any experimental animal. The value of various cholera vaccines must, at the moment, be assessed by expensive and prolonged clinical trials in those climatically difficult areas of the world where the disease is endemic. Recent field trials conducted in the Matlab Bazaar area of East Pakistan [1-7] have indicated that there is a clear correlation be-read more
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Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum
TL;DR: "Herd" immunity conferred by vaccines on viral and bacterial diseases is best explained by serum antibodies that inactivate the inoculum on mucosal surfaces, thus reducing the pathogen's transmission.
Journal ArticleDOI
Susceptibility to Vibrio cholerae Infection in a Cohort of Household Contacts of Patients with Cholera in Bangladesh
Jason B. Harris,Regina C. LaRocque,Fahima Chowdhury,Ashraful Islam Khan,Tanya Logvinenko,Abu S. G. Faruque,Edward T. Ryan,Firdausi Qadri,Stephen B. Calderwood +8 more
TL;DR: The data suggest that susceptibility to V. cholerae infection is determined by a combination of immunologic, nutritional, and genetic characteristics; additional factors that influence susceptibility to cholera remain unidentified.
Journal ArticleDOI
Protection against enteric disease caused by Escherichia coli--a model for vaccination with a virulence determinant?
J. M. Rutter,G. W. Jones +1 more
TL;DR: New knowledge of the specific determinants of microbial pathogenicity provides a sounder basis for the development of effective vaccines and the following report is an example of this approach to disease control.
Journal Article
The Estimation of the Bactericidal Power of the Blood. With a Note by J. O. IRWIN.
A. A. Miles,S. S. Misra +1 more
TL;DR: The survival rate of Staph. aureus in a standard volume of denbrinated blood is a reliable quantitative measure of the bactericidal power of blood, and the number of viable organisms in the inoculum and in the blood-bacterium mixture may be estimated with the necessary accuracy by counts of colonies developing from measured volumes of the fluids let fall on to the surface of solid media as mentioned in this paper.
Journal ArticleDOI
Synergistic protective effect in rabbits of immunization with Vibrio cholerae lipopolysaccharide and toxin/toxoid.
A M Svennerholm,J Holmgren +1 more
TL;DR: Subcutaneous immunization of rabbits with a combination of Vibrio cholerae lipopolysaccharide and enterotoxin induced a more than 100-fold-higher degree of protection against intestinal challenge with live cholera vibrios than did vaccination with either of the two antigens alone.
References
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Journal Article
Report of the 1966-67 cholera vaccine field trial in rural East Pakistan: 3. The lack of effect of prior vaccination or circulating vibriocidal antibody on the severity of clinical cholera
TL;DR: Although the presence of a high vibriocidal titre is associated with protection from cholera, pre-existing antibody had no effect on the clinical course of the disease in those patients who developed cholERA.