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The clinical correlates of reported childhood sexual abuse: an association between age at trauma onset and severity of depression and PTSD in adults.

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TLDR
Findings suggest that the impact of reported sexual abuse at different stages of development may lead to distinct psychiatric symptoms in adulthood.
Abstract
This study investigated the relationship between the age of -self-reported sexual abuse occurrence and the development of post-traumatic stress disorder and/or depressive symptoms in adulthood. Subjects were evaluated for the presence of post-traumatic stress disorder and/or depressive symptoms as well as for a self-reported history of sexual abuse before the age of 18. Results found that relative risk of having severe post-traumatic stress disorder symptoms was 10 times higher in patients reporting sexual abuse after age 12 than in those reporting sexual abuse before age 12. Relative risk of having severe depressive symptoms was higher for those abused before the age of 12 than for those abused after the age of 12. Findings suggest that the impact of reported sexual abuse at different stages of development may lead to distinct psychiatric symptoms in adulthood.

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Effects of early life stress on cognitive and affective function: an integrated review of human literature.

TL;DR: Higher-order, complex cognitive and affective functions associated with brain regions undergoing protracted postnatal development are particularly vulnerable to the deleterious effects of ELS, and the amygdala is particularly sensitive to early ELS.
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Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes

TL;DR: Phenotypic expression of psychopathology may be strongly influenced by exposure to maltreatment, leading to a constellation of ecophenotypes that fit within conventional diagnostic boundaries, but likely represent distinct subtypes.
Journal ArticleDOI

Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan

TL;DR: Longitudinal studies are needed to investigate complex ACE-related characteristics and mechanisms relevant for mental and somatic disorders by integrating state of the art knowledge and methods.
Journal ArticleDOI

Consistency in adult reporting of adverse childhood experiences.

TL;DR: Conurrent mental health factors may influence the reporting of traumatic childhood experiences and the development of depression, increasing levels of psychological distress, as well as increasing work and chronic stress were associated with an increasing likelihood of reporting a childhood adverse experience in 2006/2007 that had not been previously reported.
References
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Journal ArticleDOI

An inventory for measuring depression

TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
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The development of a Clinician-Administered PTSD Scale.

TL;DR: The Clinician-Administered PTSD Scale (CAPS-1) is a structured interview for assessing core and associated symptoms of PTSD and is intended for use by experienced clinicians, and also can be administered by appropriately trained paraprofessionals.
Journal ArticleDOI

The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description.

TL;DR: The history, rationale, and development of the Structured Clinical Interview for DSM-III-R (SCID) is described, which is a semistructured interview for making the major Axis I DSM- III-R diagnoses.
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The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

TL;DR: Preclinical studies suggest that early life stress induces long-lived hyper(re)activity of corticotropin-releasing factor (CRF) systems as well as alterations in other neurotransmitter systems, resulting in increased stress responsiveness.
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