Journal ArticleDOI
The concept of parasite-derived resistance—Deriving resistance genes from the parasite's own genome
John C. Sanford,S.A. Johnston +1 more
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A broadly-applicable strategy for genetically engineering resistance to parasites involves deriving resistance genes from the genome of the parasite itself, and the QB bacteriophage is used to illustrate, specifically, how parasite-derived resistance might be engineered.About:
This article is published in Journal of Theoretical Biology.The article was published on 1985-03-21. It has received 625 citations till now. The article focuses on the topics: Genome.read more
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Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.
TL;DR: It is proposed that the resistant state and reduced steady state levels of transgene transcript accumulation are mediated at the cellular level by a cytoplasmic activity that targets specific RNA sequences for inactivation.
Journal ArticleDOI
Control of papaya ringspot virus in papaya: a case study.
TL;DR: This review focuses on efforts to control the destructiveness of the disease caused by PSRV in Hawaii, starting from the use of cross protection to parasite-derived resistance with transgenic papaya expressing thePSRV coat protein gene.
Patent
Methods and means for obtaining modified phenotypes
TL;DR: In this paper, the authors proposed a method to reduce the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acids.
Journal ArticleDOI
Mechanisms of Pathogen-Derived Resistance to Viruses in Transgenic Plants.
TL;DR: The major emphasis is on the mechanisms of pathogen-derived resistance rather than on the practicality of using this technology for crop improvement, because these mechanisms have proven difficult to unravel.
Journal ArticleDOI
Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance
Qi-Wen Niu,Shih-Shun Lin,José L. Reyes,José L. Reyes,Kuan-Chun Chen,Kuan-Chun Chen,Kuan-Chun Chen,Hui-Wen Wu,Shyi-Dong Yeh,Nam-Hai Chua +9 more
TL;DR: In this article, an Arabidopsis thaliana miR159 precursor was modified to express artificial miRNAs (amiRNAs) targeting viral mRNA sequences encoding two gene silencing suppressors, P69 of turnip yellow mosaic virus (TYMV) and HC-Pro of TuMV (TuMV).
References
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Journal ArticleDOI
Current Status of the Gene-For-Gene Concept
TL;DR: The gene-for-gene hypothesis suggests that for each gene that conditions reaction in the host there is a correspond ing gene in the parasite that conditions pathogenicity.
Journal ArticleDOI
Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases
TL;DR: Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
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Inhibition of thymidine kinase gene expression by anti-sense RNA: A molecular approach to genetic analysis
TL;DR: Cells contransformed with flipped TK gene constructions have a reduced capacity to express subsequently microinjected TK genes, suggesting that the anti-message phenomenon is due to a trans-inhibition of TK and is probably not an artifact of rearrangements following microinjection.
Journal ArticleDOI
Characterization of the subunits of Q-beta replicase.
Robert Kamen,Robert Kamen +1 more
TL;DR: The RNA replicating enzyme induced by RNA phage Qβ consists of a single phage specific and three host specific polypeptide chains, and none are known subunits of E. coli DNA-dependent RNA polymerase.