Journal ArticleDOI
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
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The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist, which reduced neuroleptic-induced catalepsy and locomotion.Abstract:
The effects of competitive (CGP 37849 and CGP 39551) and non-competitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the non-competitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.read more
Citations
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Journal ArticleDOI
Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors
TL;DR: The results indicate that the reversible atrophy induced by 21 days of daily restraint stress requires corticosterone secretion and that excitatory mechanisms involving N-methyl-D-aspartate receptors play a major role in driving the atrophy.
Journal Article
Glycine and N-Methyl-d-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications
Wojciech Danysz,Chris G. Parsons +1 more
TL;DR: It is shown that glycine enhances electrophysiological responses mediated by N-methyl-d-aspartate (NMDA)b-sensitive glutamatergic receptors through its role as a “spatially aggregating substance” to NMDA receptors.
Journal Article
Characterization of MK-801-Induced Behavior as a Putative Rat Model of Psychosis
Peter Andiné,Nina Widermark,Rolf Axelsson,Gösta Nyberg,Ulla Olofsson,Erik Mårtensson,Mats Sandberg +6 more
TL;DR: MK-801-induced behavior represents a rat excitatory amino acid hypofunction model of psychosis that appears to be of clinical relevance and may be of value in the search for new antipsychotic agents.
Journal ArticleDOI
Glutamate receptors as therapeutic targets for Parkinson's disease.
TL;DR: Glutamate receptors represent exciting targets for the development of novel pharmacological therapies for PD as modulating the activity of these receptors may alleviate the primary motor symptoms of PD as well as side effects induced by dopamine replacement therapy.
Journal ArticleDOI
MK-801 prevents the development of behavioral sensitization during repeated morphine administration.
TL;DR: A complex interplay between NMDA and opioid receptors is suggested, such that NMDA antagonists prevent morphine sensitization while morphine enhances the ability ofNMDA antagonists to elicit sensitization to their own locomotor stimulatory effects.
References
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Journal ArticleDOI
Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion.
L.J. Herberg,I.C. Rose +1 more
TL;DR: In the present study, DCS failed to affect spontaneous locomotor activity or variable-interval self-stimulation response rate, and improvements in learning and retention reported after administration are unlikely to be accounted for by nonassociative motivational, or performance, factors.
Book ChapterDOI
Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists
TL;DR: Both competitive and non-competitive NMDA antagonists have cerebroprotective activity in a number of ischemia, hypoxia and trauma models, as well as anticonvulsant activity ina wide range of animal seizure models, and correlate well with their affinities for the NMDA receptor.
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