Journal ArticleDOI
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
Reads0
Chats0
TLDR
The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist, which reduced neuroleptic-induced catalepsy and locomotion.Abstract:
The effects of competitive (CGP 37849 and CGP 39551) and non-competitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the non-competitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.read more
Citations
More filters
Journal ArticleDOI
MK-801 does not prevent acute stimulatory effects of amphetamine or cocaine on locomotor activity or extracellular dopamine levels in rat nucleus accumbens
TL;DR: The results suggest that the acute effects of cocaine and amphetamine on locomotor activity and extracellular DA levels are not prevented byMK-801, and that MK-801 must act through other mechanisms to prevent the development of behavioral sensitization.
Journal ArticleDOI
NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice.
TL;DR: The findings suggest that the anticonvulsant properties of riluzole depend upon its interaction with neurotransmission mediated by both the glycine/NMDA and the AMPA/kainate receptor complex.
Journal ArticleDOI
Competitive and non-competitive NMDA receptor antagonists in spatial learning tasks.
TL;DR: The effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonists and its ethyl ester CGP39551 and of the non-competitive NMDA receptor antagonist, dizocilpine on acquisition by rats of different spatial orientation tasks in an 8-arm radial maze were evaluated.
Journal ArticleDOI
MK-801 Potentiates Ethanol’s Effects on Locomotor Activity in Mice
TL;DR: The data suggest that NMDA receptors modulate ethanol's stimulant properties, by a more significant involvement in expression of ethanol's locomotor depressant properties.
Journal ArticleDOI
Effects of l-dopa and bromocriptine on haloperidol-induced motor deficits in mice
Tsuneyasu Kobayashi,Tsutomu Araki,Yasuto Itoyama,Mitsuhiro Takeshita,Tomihisa Ohta,Yoshiteru Oshima +5 more
TL;DR: The results indicate that co-administration with L-DOPA + carbidopa and single treatment with bromocriptine can decrease haloperidol-induced catalepsy and bradykinesia in mice and suggests that pole test as well as cat alepsy test is of value in the screening of drugs against neuroleptic-induced motor deficits.
References
More filters
Journal ArticleDOI
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum.
TL;DR: Recovery of behavioural effects correlated with an increase in the remaining levels of DA in the NAS, and there is evidence that remaining DA levels in theNAS are greater at 90 than at 14 days postoperatively.
Journal ArticleDOI
Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
TL;DR: In voltage-clamped oocytes, neither perfusion nor rapid pressure application of NMDA onto messenger RNA-injected oocytes caused a distinct ionic current without added glycine, but when glycine was added, NMDA evoked large inward currents.
Journal ArticleDOI
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
TL;DR: The distribution of NMDA-sensitive L-[3H]glutamate-binding sites suggests that the NMDA receptor represents a major, distinct subset of excitatory amino acid receptors and indicates regions in which neurotransmission may be mediated or modulated by this receptor.
Related Papers (5)
Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats.
Werner J. Schmidt,Michael Bubser +1 more
The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice
Maria L. Carlsson,Arvid Carlsson +1 more
Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease
Maria L. Carlsson,Arvid Carlsson +1 more