Journal ArticleDOI
The cost effectiveness of treating paediatric cancer in low-income and middle-income countries: a case-study approach using acute lymphocytic leukaemia in Brazil and Burkitt lymphoma in Malawi
TLDR
Treatment of certain paediatric cancers in LMIC is very cost effective, and future research should evaluate actual treatment and infrastructure expenditures to help guide policymakers.Abstract:
Approximately 90% of children with cancer reside in low-income and middle-income countries (LMIC) where healthcare resources are scarce and allocation decisions difficult. The cost effectiveness of treating childhood cancers in these settings is unknown. The objective of the present work was to determine cost-effectiveness thresholds for common paediatric cancers using acute lymphoblastic leukaemia (ALL) in Brazil and Burkitt lymphoma (BL) in Malawi as examples. Disability-adjusted life years (DALYs) prevented by treatment were compared to the gross domestic product (GDP) per capita of each country to define cost-effectiveness thresholds using WHO-CHOICE ('CHOosing Interventions that are Cost-Effective') guidelines. The case examples were selected due to the data available and because ALL and BL both have the potential to yield significant health gains at a low cost per patient treated. The key findings were as follows: the 3:1 cost/DALY prevented to GDP/capita ratio for ALL in Brazil was US $771,225; expenditures below this threshold were cost effective. Costs below US $257,075 (1:1 ratio) were considered very cost effective. Analogous thresholds for BL in Malawi were US $42,729 and US $14,243. Actual costs were far less. In Brazil, US $16,700 was spent to treat each patient while in Malawi total drug costs were less than US $50 per child. In summary, treatment of certain paediatric cancers in LMIC is very cost effective. Future research should evaluate actual treatment and infrastructure expenditures to help guide policymakers.read more
Citations
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Childhood and adolescent cancer statistics, 2014
TL;DR: Estimates of the number of new cancer cases and deaths for children and adolescents in the United States are provided and an overview of risk factors, symptoms, treatment, and long‐term and late effects for common pediatric cancers are provided.
Journal ArticleDOI
Paediatric cancer in low-income and middle-income countries
Ian Magrath,Eva Steliarova-Foucher,Sidnei Epelman,Raul C. Ribeiro,Mhamed Harif,Chi Kong Li,Rejin Kebudi,Scott D Macfarlane,Scott C. Howard +8 more
TL;DR: This work discusses childhood cancer in relation to global development and proposes strategies that could result in improved survival and education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care.
Journal ArticleDOI
Childhood cancer burden: a review of global estimates.
Nickhill Bhakta,Lisa M. Force,Claudia Allemani,Rifat Atun,Freddie Bray,Michel P Coleman,Eva Steliarova-Foucher,A. Lindsay Frazier,Leslie L. Robison,Carlos Rodriguez-Galindo,Christina Fitzmaurice,Christina Fitzmaurice +11 more
TL;DR: This Review analyzes four studies of the global cancer burden that included data for children and adolescents and proposes several recommendations to strengthen data collection and standardise analyses that could help stakeholders to develop plans for national and institutional cancer programmes.
Iconographies supplémentaires de l'article : Abandonment of treatment for childhood cancer: position statement of a SIOP PODC Working Group
Saskia Mostert,Ramandeep Singh Arora,Magda Arreola,Poonam Bagai,Paola Friedrich,Sumit Gupta,Geetinder Kaur,Bindu Koodiyedath,Ketan Kulkarni,Catherine G. Lam,Sandra Luna-Fineman,Barry Pizer,Silvia Rivas,Nuria Rossell,Mei Neni Sitaresmi,Argerie Tsimicalis,Meaghann S. Weaver,Raul C. Ribeiro +17 more
Journal ArticleDOI
Sustainable care for children with cancer: a Lancet Oncology Commission
Rifat Atun,Nickhill Bhakta,Avram Denburg,A. Lindsay Frazier,Paola Friedrich,Sumit Gupta,Catherine G. Lam,Zachary J. Ward,Jennifer M. Yeh,Jennifer M. Yeh,Claudia Allemani,Michel P Coleman,Veronica Di Carlo,Eva M. Loucaides,Elizabeth J. A. Fitchett,Fabio Girardi,Susan Horton,Freddie Bray,Eva Steliarova-Foucher,Richard Sullivan,Joanne F. Aitken,Joanne F. Aitken,Shripad Banavali,Agnes Binagwaho,Patricia Alcasabas,Federico Antillon,Ramandeep Singh Arora,Ronald D. Barr,Eric Bouffet,Julia Challinor,Soad Fuentes-Alabi,Thomas G. Gross,Lars Hagander,Ruth I. Hoffman,Cristian A Herrera,Cristian A Herrera,Tezer Kutluk,Karen J. Marcus,Karen J. Marcus,Claude Moreira,Kathy Pritchard-Jones,Oscar Ramirez,Lorna Renner,Lorna Renner,Leslie L. Robison,Jaime Shalkow,Lillian Sung,Allen Eng Juh Yeoh,Carlos Rodriguez-Galindo +48 more
TL;DR: The burden of childhood cancer, which has been grossly underestimated in the past, can be effectively diminished to realise massive health and economic benefits and to avert millions of needless deaths.
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Journal ArticleDOI
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