Journal ArticleDOI
The crystal structure of catechol oxidase : new insight into the function of type-3 copper proteins
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Comparison between the 3D structures of catechol oxidase and hemocyanins reveals the structural reasons for the divergence in function.Abstract:
The crystal structure of catechol oxidase reveals new insight into the functional properties of the type-3 copper proteins. This class of proteins includes the closely related and better-known tyrosinase as well as hemocyanin, an oxygen transport protein. All these proteins have a dinuclear copper center, have similar spectroscopic behaviors, and show close evolutionary and functional relationships. Comparison between the 3D structures of catechol oxidase and hemocyanins reveals the structural reasons for the divergence in function.read more
Citations
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Journal ArticleDOI
Aerobic Copper-Catalyzed Organic Reactions
TL;DR: The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and CuIII oxidation states allowing it to act through one-electron or two-Electron processes, which feature confer a remarkably broad range of activities allowing copper to catalyze the oxidation and oxidative union of many substrates.
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An Updated Review of Tyrosinase Inhibitors
TL;DR: This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.
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Structure and Spectroscopy of Copper−Dioxygen Complexes
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Principles of mononucleating and binucleating ligand design.
Anna L. Gavrilova,B. Bosnich +1 more
References
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Journal ArticleDOI
Multicopper Oxidases and Oxygenases
TL;DR: Copper sites have historically been divided into three classes based on their spectroscopic features, which reflect the geometric and electronic structure of the active site: type 1 or blue copper, type 2 (T2) or normal copper, and type 3 (T3) or coupled binuclear copper centers.
Journal ArticleDOI
Polyphenol oxidases in plants
Alfred M. Mayer,Eitan Harel +1 more
TL;DR: Two main groups of plant polyphenol oxidases are recognized: the catecholoxidases and the laccases: their purification, subcellular location and protein properties are described.
Journal ArticleDOI
Tyrosinase: a comprehensive review of its mechanism.
Álvaro Sánchez-Ferrer,José Neptuno Rodríguez-López,Francisco García-Cánovas,Francisco García-Carmona +3 more
Journal ArticleDOI
Survival for immunity: the price of immune system activation for bumblebee workers.
Yannick Moret,Paul Schmid-Hempel +1 more
TL;DR: Workers of the bumblebee were challenged with lipopolysaccharides and micro-latex beads to induce their immune system under starvation to reduce host fitness, and survival of induced workers was significantly reduced.