The dialectic of Hebb and homeostasis.
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TLDR
Some of the recent progress in the field of Hebbian and homeostatic plasticity is described, as well as some of the deep puzzles that remain.Abstract:
It has become widely accepted that homeostatic and Hebbian plasticity mechanisms work hand in glove to refine neural circuit function. Nonetheless, our understanding of how these fundamentally dist...read more
Citations
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Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
Boaz Styr,Inna Slutsky +1 more
TL;DR: A hypothesis is suggested to explain the transition from ‘silent’ signatures of aberrant neural circuit activity to clinically evident memory impairments and failures in firing homeostasis and imbalance between stability and plasticity represent the driving force of early disease progression.
Journal ArticleDOI
Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions
Tara Keck,Taro Toyoizumi,Lu Chen,Brent Doiron,Daniel E. Feldman,Kevin Fox,Wulfram Gerstner,Philip G. Haydon,Mark Hübener,Hey Kyoung Lee,John E. Lisman,Tobias Rose,Frank Sengpiel,Frank Sengpiel,David Stellwagen,Michael P. Stryker,Gina G. Turrigiano,Mark C. W. van Rossum +17 more
TL;DR: Potential directions of research that are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain are suggested.
Journal ArticleDOI
Hebbian plasticity requires compensatory processes on multiple timescales.
TL;DR: It is suggested that learning and memory rely on an intricate interplay of diverse plasticity mechanisms on different timescales which jointly ensure stability and plasticity of neural circuits.
Journal ArticleDOI
Cortical Circuit Dynamics Are Homeostatically Tuned to Criticality In Vivo.
TL;DR: The results suggest that criticality in excitatory networks is established by inhibitory plasticity and architecture, and suggest a key role for homeostatic regulation of inhibition in visual cortical circuits.
Journal ArticleDOI
Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation
Francesca Romana Rizzo,Alessandra Musella,Francesca De Vito,Diego Fresegna,Silvia Bullitta,Valentina Vanni,Livia Guadalupi,Mario Stampanoni Bassi,Fabio Buttari,Georgia Mandolesi,Diego Centonze,Antonietta Gentile +11 more
TL;DR: Current evidence of the role of IL-1β and TNF in the regulation of synaptic strength at both physiological and pathological levels are introduced and discussed, in particular speculating on their involvement in the synaptic plasticity changes observed in the EAE brain.
References
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Sleep Drives Metabolite Clearance From the Adult Brain
Lulu Xie,Hongyi Kang,Qiwu Xu,Michael Chen,Yonghong Liao,Meenakshisundaram Thiyagarajan,John O’Donnell,Daniel J. Christensen,Charles Nicholson,Jeffrey J. Iliff,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
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Homeostatic plasticity in the developing nervous system
TL;DR: Evidence is discussed from a number of systems that homeostatic synaptic plasticity is crucial for processes ranging from memory storage to activity-dependent development, and how these processes maintain stable activity states in the face of destabilizing forces is discussed.
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Activity-dependent scaling of quantal amplitude in neocortical neurons
TL;DR: A new form of synaptic plasticity is described that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity, and may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs.
Journal ArticleDOI
Synaptic plasticity: taming the beast
L. F. Abbott,Sacha B. Nelson +1 more
TL;DR: This work reviews three Hebbian forms of plasticity—synaptic scaling, spike-timing dependent plasticity and synaptic redistribution—and discusses their functional implications.