Journal ArticleDOI
The epidemiology of osteoarthritis
TLDR
The purpose of this review is to illustrate how each of these factors interact together to instigate incident OA as well as to outline the need for ongoing epidemiologic studies for the future prevention of both incident and progressive OA.Abstract:
Osteoarthritis (OA) is a leading cause of disability and its incidence is rising due to increasing obesity and an ageing population. Risk factors can be divided into person-level factors, such as age, sex, obesity, genetics, race/ethnicity and diet, and joint-level factors including injury, malalignment and abnormal loading of the joints. The interaction of these risk factors is complex and provides a challenge to the managing physician. The purpose of this review is to illustrate how each of these factors interact together to instigate incident OA as well as to outline the need for ongoing epidemiologic studies for the future prevention of both incident and progressive OA. It is only by understanding the impact of this disease and the modifiable risk factors that we will be able to truly target public health prevention interventions appropriately.read more
Citations
More filters
Journal ArticleDOI
Ageing and the pathogenesis of osteoarthritis
TL;DR: Improved understanding of ageing-related mechanisms that promote OA could lead to the discovery of new targets for therapies that aim to slow or stop the progression of this chronic and disabling condition.
Journal ArticleDOI
Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis.
TL;DR: The first formalized attempts at establishing a radiographic classification scheme for OA were described by Kellgren and Lawrence (KL) in 1957 and found that the tibiofemoral joint of the knee had the highest interobserver correlation coefficient.
Journal ArticleDOI
Epidemiology of osteoarthritis: literature update.
Ernest R. Vina,C. Kent Kwoh +1 more
TL;DR: This review highlights recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors, which may allow us to develop innovative strategies and novel therapies for preventing new disease onset and minimizing disease progression.
Journal ArticleDOI
Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk
TL;DR: The changes that occur in bone and cartilage during the osteoarthritic process are described, and strategies for how this knowledge could be applied to develop new therapeutic interventions for osteOarthritis are highlighted.
Journal ArticleDOI
The Dramatic Increase in Total Knee Replacement Utilization Rates in the United States Cannot Be Fully Explained by Growth in Population Size and the Obesity Epidemic
TL;DR: In this paper, the authors used data from the Nationwide Inpatient Sample to estimate changes in total knee replacement utilization rates from 1999 to 2008, stratified by age (eighteen to forty-four, forty-five to sixty-four years, and sixty-five years or older).
References
More filters
Journal ArticleDOI
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
Reva C. Lawrence,David T. Felson,Charles G. Helmick,Lesley M. Arnold,Hyon K. Choi,Richard A. Deyo,Sherine E. Gabriel,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Joanne M. Jordan,Jeffrey N. Katz,Hilal Maradit Kremers,Frederick Wolfe +13 more
TL;DR: This report provides the best available prevalence estimates for the US for osteoarthritis, polymyalgia rheumatica, gout, fibromyalgia, and carpal tunnel syndrome as well as the symptoms of neck and back pain.
National Arthritis Data Work-group. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
Reva C. Lawrence,David T. Felson,Charles G. Helmick,LM Arnold,Hyon K. Choi,Richard A. Deyo,LM Helmick Cg Arnold,Sherine E. Gabriel,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Joanne M. Jordan,Jeffrey N. Katz,Hilal Maradit Kremers,Frederick Wolfe,FC Arnett +15 more
TL;DR: In this paper, the best available estimates of the US prevalence of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as the symptoms of neck and back pain are provided.
Journal ArticleDOI
Osteoarthritis: New Insights Part 1: The Disease and Its Risk Factors
David T. Felson,Reva C. Lawrence,Paul Dieppe,Rosemarie Hirsch,C. G. Helmick,Joanne M. Jordan,Raynard Kington,Nancy E Lane,Michael C. Nevitt,Yuqing Zhang,M. Sowers,Timothy E. McAlindon,Tim D. Spector,A. R. Poole,Susan Z. Yanovski,Gerard A. Ateshian,Leena Sharma,Joseph A. Buckwalter,Kenneth D. Brandt,James F. Fries +19 more
TL;DR: This article is part 1 of a two-part summary of an NIH conference, Stepping Away with OA: Prevention of Onset, Progression, and Disability of Osteoarthritis, which brought together experts in osteoarth arthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention.
Journal ArticleDOI
The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries Osteoarthritis
TL;DR: The objectives of this study are to review the long-term consequences of injuries to the anterior cruciate ligament and menisci, the pathogenic mechanisms, and the causes of the considerable variability in outcome, and to strive toward a comparable level of quality of evidence in surgical treatment of knee injuries.
Journal ArticleDOI
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.
Andrew A. Guccione,David T. Felson,Jennifer J. Anderson,John Anthony,Yuqing Zhang,Peter W.F. Wilson,Margaret Kelly-Hayes,Philip A. Wolf,Bernard E. Kreger,W B Kannel +9 more
TL;DR: In general, stroke, depressive symptomatology, hip fracture, knee osteoarthritis, and heart disease account for more physical disability in noninstitutionalized elderly men and women than other diseases.