Epidemiology of osteoarthritis: literature update.
Ernest R. Vina,C. Kent Kwoh +1 more
TLDR
This review highlights recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors, which may allow us to develop innovative strategies and novel therapies for preventing new disease onset and minimizing disease progression.Abstract:
Purpose of reviewThe purpose of this review is to highlight recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors.Recent findingsOsteoarthritis is highly prevalent in the United States and around the globe. It is a leading cause oread more
Citations
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Journal ArticleDOI
Global, regional and national burden of osteoarthritis 1990-2017: A systematic analysis of the Global Burden of Disease Study 2017
Saeid Safiri,Ali-Asghar Kolahi,Damian G Hoy,Emma Smith,Deepti Bettampadi,Mohammad Ali Mansournia,Amir Almasi-Hashiani,Ahad Ashrafi-Asgarabad,Maziar Moradi-Lakeh,Mostafa Qorbani,Gary S. Collins,Anthony D. Woolf,Lyn March,Marita Cross +13 more
TL;DR: The global prevalence was higher in women and increased with age, peaking at the >95 age group among women and men in 2017, and a positive association was found between the age-standardised YLD rate and SDI at the regional and national levels.
Journal ArticleDOI
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
TL;DR: The global prevalence and incidence of knee OA varied substantially between individual countries and increased with age, and these findings can be used to better assess the global health burden of knees OA.
Journal ArticleDOI
Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations.
Dragan Primorac,Vilim Molnar,Eduard Rod,Željko Jeleč,Fabijan Čukelj,Vid Matišić,Trpimir Vrdoljak,Damir Hudetz,Hana Hajsok,Igor Borić +9 more
TL;DR: All of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment of osteoarthritis is summarized.
Journal ArticleDOI
Exosomes: roles and therapeutic potential in osteoarthritis
Zhenhong Ni,Siru Zhou,Song Li,Liang Kuang,Hangang Chen,Xiaoqing Luo,Junjie Ouyang,Mei He,Xiaolan Du,Lin Chen +9 more
TL;DR: The roles and therapeutic potential of exosomes in OA are summarized and the perspectives and challenges related to exosome-based treatment for OA patients in the future are discussed.
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LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Manoj Arra,Gaurav Swarnkar,Ke Ke,Jesse E. Otero,Jun Ying,Xin Duan,Takashi Maruyama,Muhammad Farooq Rai,Regis J. O'Keefe,Gabriel Mbalaviele,Jie Shen,Yousef Abu-Amer,Yousef Abu-Amer +12 more
TL;DR: It is shown that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, which drives cartilage catabolism, which identifies LDHA as a potential therapeutic target for OA treatment.
References
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Journal ArticleDOI
The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Marita Cross,Emma Smith,Damian G Hoy,Sandra Nolte,Ilana N. Ackerman,Marlene Fransen,Lisa Bridgett,Sean R.M. Williams,Francis Guillemin,Christopher Hill,Laura L Laslett,Graeme Jones,Flavia M. Cicuttini,Richard H. Osborne,Theo Vos,Rachelle Buchbinder,Anthony D. Woolf,Lyn March +17 more
TL;DR: In this article, the global burden of hip and knee OA was estimated as part of the Global Burden of Disease 2010 study and the burden of OA compared with other conditions.
Journal ArticleDOI
Epidemiology of Osteoarthritis
Yuqing Zhang,Joanne M. Jordan +1 more
TL;DR: Modifying factors that play roles in the development of joint OA may reduce the risk of OA and prevent subsequent pain and disability, particularly in the weight-bearing joints.
Journal ArticleDOI
The epidemiology of osteoarthritis
TL;DR: The purpose of this review is to illustrate how each of these factors interact together to instigate incident OA as well as to outline the need for ongoing epidemiologic studies for the future prevention of both incident and progressive OA.
Journal ArticleDOI
Epidemiology of OA
Tuhina Neogi,Yuqing Zhang +1 more
TL;DR: Risk factors for OA include a number of person-level factors, such as age, sex, obesity, and genetics, as well as joint-specific factors that are likely reflective of abnormal loading of the joints.
Journal ArticleDOI
Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity.
Bhushan R. Deshpande,Jeffrey N. Katz,Daniel H. Solomon,Edward H. Yelin,David J. Hunter,Stephen P. Messier,Lisa G. Suter,Elena Losina +7 more
TL;DR: The prevalence of symptomatic knee osteoarthritis has been increasing over the past several decades in the US, concurrent with an aging population and the growing obesity epidemic and the impact of these factors on the number of persons with symptomatic knees OA in the early decades of the 21st century is quantified.
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