Journal ArticleDOI
The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity.
TLDR
It seems that mutation by gene duplication and inactivation has important roles in both the adaptive and non-adaptive evolution of chemosensation.Abstract:
Chemosensory receptors are essential for the survival of organisms that range from bacteria to mammals. Recent studies have shown that the numbers of functional chemosensory receptor genes and pseudogenes vary enormously among the genomes of different animal species. Although much of the variation can be explained by the adaptation of organisms to different environments, it has become clear that a substantial portion is generated by genomic drift, a random process of gene duplication and deletion. Genomic drift also generates a substantial amount of copy-number variation in chemosensory receptor genes within species. It seems that mutation by gene duplication and inactivation has important roles in both the adaptive and non-adaptive evolution of chemosensation.read more
Citations
More filters
Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal ArticleDOI
Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction
Vincent Croset,Raphael Rytz,Scott F. Cummins,Aidan Budd,David Brawand,Henrik Kaessmann,Toby J. Gibson,Richard Benton +7 more
TL;DR: It is shown that IRs are expressed in olfactory organs across Protostomia—a major branch of the animal kingdom that encompasses arthropods, nematodes, and molluscs—indicating that they represent an ancestral protostome chemosensory receptor family.
Journal ArticleDOI
Divergence of duplicate genes in exon–intron structure
TL;DR: Analysis of sibling paralogs from seven representative gene families and 300 pairs of one-to-one orthologs from different species found that structural divergences have been very prevalent in duplicate genes and, in many cases, have led to the generation of functionally distinctParalogs.
Journal ArticleDOI
Gene duplication as a mechanism of genomic adaptation to a changing environment
TL;DR: The identification of copy-number variation in ecological field studies of species adapting to stressful or novel environmental conditions may improve the understanding of gene duplication as a mechanism of adaptation and its relevance to the long-term persistence of gene duplications.
Journal ArticleDOI
Functional Architecture of Olfactory Ionotropic Glutamate Receptors
Liliane Abuin,Benoîte Bargeton,Maximilian H. Ulbrich,Ehud Y. Isacoff,Ehud Y. Isacoff,Stephan Kellenberger,Richard Benton +6 more
TL;DR: This work demonstrates that IRs act in combinations of up to three subunits, comprising individual odor-specific receptors and one or two broadly expressed coreceptors, and provides insights into the conserved and distinct architecture of these olfactory and synaptic ion channels.
References
More filters
Book
Molecular Evolutionary Genetics
TL;DR: Recent developments of statistical methods in molecular phylogenetics are reviewed and it is shown that the mathematical foundations of these methods are not well established, but computer simulations and empirical data indicate that currently used methods produce reasonably good phylogenetic trees when a sufficiently large number of nucleotides or amino acids are used.
Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal ArticleDOI
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated in this article.
Journal ArticleDOI
PAML 4: Phylogenetic Analysis by Maximum Likelihood
TL;DR: PAML, currently in version 4, is a package of programs for phylogenetic analyses of DNA and protein sequences using maximum likelihood (ML), which can be used to estimate parameters in models of sequence evolution and to test interesting biological hypotheses.
Related Papers (5)
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more