Open AccessJournal Article
The Evolution of the Immune Response VIII. Structural Studies of the Lamprey Immunoglobulin
Reads0
Chats0
TLDR
The observations presented show that the lamprey immunoglobulin lacks counterparts of heavy and light chains and does not possess interchain disulfide linkages between its major subunits.Abstract:
Highly purified preparations of radiolabeled lamprey immunoglobulin have been employed to study the structure of the immunoglobulin of this primitive vertebrate. The identity of the labeled material with that of the native immunoglobulin has been established. The lamprey immunoglobulin appears to be unique among vertebrate immunoglobulins since it has a unique molecular weight, electrophoretic mobility, and sedimentation velocity. It is also extremely labile and dissociates in solvents in a complex manner. The observations presented show that this molecule lacks counterparts of heavy and light chains and does not possess interchain disulfide linkages between its major subunits. A structural model based on its dissociation behavior is presented and the implications of such a structure in terms of molecular function and phylogenetic development are discussed.read more
Citations
More filters
Journal ArticleDOI
Origin and evolution of the adaptive immune system: genetic events and selective pressures
TL;DR: Insight is offered into the latest advances in this field of adaptive immune system research and speculate on the selective pressures that led to the emergence and maintenance of the AIS.
Journal ArticleDOI
The evolution of adaptive immune systems.
Max D. Cooper,Matthew N. Alder +1 more
TL;DR: The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components.
Journal ArticleDOI
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
Zeev Pancer,Chris T. Amemiya,Götz R. A. Ehrhardt,Jill Ceitlin,G. Larry Gartland,Max D. Cooper +5 more
TL;DR: The search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of variable lymphocyte receptors (VLRs) composed of highly diverse leucine-rich repeats (LRR) sandwiched between amino- and carboxy-terminal LRRs.
Journal ArticleDOI
Noncellular nonspecific defence mechanisms of fish
J. B. Alexander,George A. Ingram +1 more
TL;DR: Fish tissues and body fluids contain naturally occurring proteins or glycoproteins of non-immunoglobulin (Ig) nature that react with a diverse array of environmental antigens and may confer an undefined degree of natural immunity to fish.
Journal ArticleDOI
Substances involved in the natural resistance of fish to infection - a review.
TL;DR: Fish contain naturally-occurring, relatively nonspecific, lectin-like proteins or glycoproteins, which are distinct from immunoglobulins, and which react with a wide variety of antigens and may confer some degree of immunity against natural infection.
Related Papers (5)
Phylogenetic origins of antibody structure iii. antibodies in the primary immune response of the sea lamprey, petromyzon marinus
The evolution of the immune response iii. immunologic responses in the lamprey
Joanne Finstad,Robert A. Good +1 more