Journal ArticleDOI
The graft response to transplantation: a gene expression profile analysis.
Kenneth B. Christopher,Thomas F. Mueller,Rachel DeFina,Yurong Liang,Jianhua Zhang,Robert Gentleman,David L. Perkins +6 more
TLDR
The results identify novel components of the graft response to transplantation injury and rejection that are identified in genes classified as defense, communication, and metabolism.Abstract:
Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutiv...read more
Citations
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Journal ArticleDOI
Arraying the orchestration of allograft pathology
TL;DR: The current literature of microarray use in transplantation research is reviewed, currently available array platforms are compared, and future application of this technology to clinical organ transplantation is discussed.
Journal ArticleDOI
Novel Insights into Lung Transplant Rejection by Microarray Analysis
TL;DR: Microarrays were used to assess gene expression in bronchoalveolar lavage cell samples from lung transplant recipients with and without acute rejection on simultaneous lung biopsies and showed increased expression during acute rejection of genes involved in inflammation, apoptosis, and T-cell activation and proliferation.
Journal ArticleDOI
Microarrays: a monitoring tool for transplant patients?
TL;DR: The current applications of microarray technology in the field of transplantation are reviewed, and the potential impact of this technology on monitoring of solid organ transplant recipients is discussed.
Journal ArticleDOI
Activation of counter-regulatory mechanisms in a rat renal acute rejection model
Bayram Edemir,Sunil M. Kurian,Martin Eisenacher,Detlef Lang,Carsten Müller-Tidow,Gert Gabriëls,Daniel R. Salomon,Eberhard Schlatter +7 more
TL;DR: There is simultaneous activation of pathways for counter regulatory and protective mechanisms that would balance and limit the ongoing inflammatory/immune responses, in parallel with the predicted activation of immune response and tissue injury pathways.
Patent
Biomarkers for graft rejection
TL;DR: In this article, methods for diagnosing rejection in a transplanted subject, monitoring rejection, and identifying agents for use in the prevention, inhibition, reduction or treatment of rejection based on genes which are differentially expressed in transplanted subjects.
References
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M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
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Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
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Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
Pablo Tamayo,Donna K. Slonim,Jill P. Mesirov,Qing Zhu,Sutisak Kitareewan,Ethan Dmitrovsky,Eric S. Lander,Todd R. Golub,Todd R. Golub +8 more
TL;DR: In this article, the application of self-organizing maps, a type of mathematical cluster analysis that is particularly well suited for recognizing and classifying features in complex, multidi-mensional data, is described.
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Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.
Trey Ideker,Vesteinn Thorsson,Jeffrey A. Ranish,Rowan H. Christmas,Jeremy Buhler,Jimmy K. Eng,Roger E. Bumgarner,David R. Goodlett,Ruedi Aebersold,Leroy Hood +9 more
TL;DR: An integrated approach to build, test, and refine a model of a cellular pathway, in which perturbations to critical pathway components are analyzed using DNA microarrays, quantitative proteomics, and databases of known physical interactions, suggests hypotheses about the regulation of galactose utilization and physical interactions between this and a variety of other metabolic pathways.
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Left Ventricular Remodeling After Myocardial Infarction Pathophysiology and Therapy
TL;DR: This article will review postinfarction remodeling, pathophysiological mechanisms, and therapeutic intervention in left ventricular remodeling and provide important insights into the remodeling process and a rationale for future therapeutic strategies.