The habenula encodes negative motivational value associated with primary punishment in humans
Rebecca P. Lawson,Benjamin Seymour,Eleanor Loh,Antoine Lutti,Antoine Lutti,Raymond J. Dolan,Peter Dayan,Nikolaus Weiskopf,Jonathan P. Roiser +8 more
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TLDR
It is established that the habenula encodes associations with aversive outcomes in humans, specifically that it tracks the dynamically changing negative values of cues paired with painful electric shocks, consistent with a role in learning.Abstract:
Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.read more
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Impaired reward prediction error encoding and striatal-midbrain connectivity in depression
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Lateral habenula in the pathophysiology of depression.
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The Lateral Habenula Circuitry: Reward Processing and Cognitive Control.
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TL;DR: This work highlights recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions.
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