The Hypoxia-Long Noncoding RNA Interaction in Solid Cancers.
Seung Wan Son,Ba Da Yun,Mun Gyu Song,Jin Kyeong Lee,Soo Young Choi,Hyo Jeong Kuh,Jong Kook Park +6 more
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TLDR
In this paper, the relationship between hypoxia/HIFs and long noncoding RNAs (lncRNAs) has been investigated and the possibility of lncRNas as candidate molecules for controlling cancer was discussed.Abstract:
Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.read more
Citations
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Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha.
TL;DR: In this article, the anti-cancer effect of phytochemicals in connection with HIF-1α regulation has been evaluated, and they have been found to possess significant therapeutic potentials against numerous cancer types.
Journal ArticleDOI
Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers
Ba Yun,Ye Ji Choi,Seung Wan Son,Gabriel Adelman Cipolla,Fernanda Costa Brandão Berti,Danielle Malheiros,Tae-Jin Oh,Hyo-Jeong Kuh,Soo Young Choi,Jong Kook Park +9 more
TL;DR: The function and intrinsic features of oncogenic circRNAs and lncRNAs that are enriched within exosomes are discussed, which are critical for cell–cell communication within the cancer microenvironment.
Journal ArticleDOI
Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
Mohammad Roshani,Ghazaleh Baniebrahimi,Mahboubeh Mousavi,Noushid Zare,Reza Sadeghi,Reza Salarinia,Amirhossein Sheida,Danial Molavizadeh,Sara Sadeghi,Farzaneh Moammer,Mohammad Reza Zolfaghari,Hamed Mirzaei +11 more
TL;DR: The role of exosomal lncRNAs in the biology and possible future treatment of GI cancer was discussed in this article , where they were employed as biomarkers for the diagnosis and prognosis of cancer.
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Hydrogels for Antitumor and Antibacterial Therapy
TL;DR: The advantages and representative applications of hydrogels in these fields are highlighted and the shortages and future orientations of this useful tool are outlined, which might give inspirations for future studies.
Journal ArticleDOI
Noncoding RNAs as sensors of tumor microenvironmental stress
TL;DR: In this paper , the authors elaborate on the signal transduction pathways or epigenetic pathways by which hypoxia-inducible factors (HIFs), inflammatory factors, and nutrient deprivation in TME regulate ncRNAs.
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